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Database: UniProt
Entry: W5UEY8_ICTPU
LinkDB: W5UEY8_ICTPU
Original site: W5UEY8_ICTPU 
ID   W5UEY8_ICTPU            Unreviewed;      3624 AA.
AC   W5UEY8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 43.
DE   SubName: Full=Cubilin {ECO:0000313|EMBL:AHH40129.1, ECO:0000313|RefSeq:XP_017330258.1};
GN   Name=CUBN {ECO:0000313|EMBL:AHH40129.1};
GN   Synonyms=cubn {ECO:0000313|RefSeq:XP_017330258.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH40129.1};
RN   [1] {ECO:0000313|EMBL:AHH40129.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mixed {ECO:0000313|EMBL:AHH40129.1};
RX   PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA   Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA   Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA   Peatman E., Liu Z.;
RT   "Efficient assembly and annotation of the transcriptome of catfish by
RT   RNA-Seq analysis of a doubled haploid homozygote.";
RL   BMC Genomics 13:595-595(2012).
RN   [2] {ECO:0000313|RefSeq:XP_017330258.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017330258.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; JT413156; AHH40129.1; -; mRNA.
DR   RefSeq; XP_017330258.1; XM_017474769.1.
DR   GeneID; 108269153; -.
DR   KEGG; ipu:108269153; -.
DR   CTD; 8029; -.
DR   KO; K14616; -.
DR   OrthoDB; 4105at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 27.
DR   Gene3D; 2.60.120.290; -; 27.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 27.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 3.
DR   Pfam; PF12661; hEGF; 1.
DR   SMART; SM00042; CUB; 27.
DR   SMART; SM00181; EGF; 8.
DR   SMART; SM00179; EGF_CA; 7.
DR   SUPFAM; SSF49854; SSF49854; 27.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS01180; CUB; 27.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS01187; EGF_CA; 3.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23   3624       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013540226.
FT   DOMAIN      129    165       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      167    208       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      348    388       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      395    431       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      433    469       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      475    589       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      593    705       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      711    823       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      824    935       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      939   1052       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1058   1170       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1174   1286       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1287   1402       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1404   1519       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1523   1635       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1636   1752       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1756   1868       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1869   1981       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1995   2108       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2109   2225       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2229   2345       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2347   2459       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2463   2576       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2580   2695       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2697   2809       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2813   2927       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2928   3039       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3041   3154       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3161   3275       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3279   3394       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3396   3508       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3512   3624       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   COILED       74     94       {ECO:0000256|SAM:Coils}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
FT   DISULFID    155    164       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    198    207       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    359    376       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    421    430       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    459    468       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2347   2374       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   2580   2607       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   3041   3068       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   3624 AA;  394126 MW;  5764A114D6CAEA63 CRC64;
     MAWTFRLSWP LIALLFLSGL QCEQGKRAHS RSKRDISDAQ PRMISKDGHL TFMPGNNKDI
     HFDTSGTGHV KVGNEDLTEL LKQIKTNKDD IESIKNSGPS QEVQNQLNQL NTKVATLESK
     VQTVEQTIQR KTCSSNPCQN TGTCLNLLDS FHCLCPQNWQ GPICAVDVNE CQIYAGTTQG
     CQNGATCVNT PGSYTCNCLP EWYGPHCTSR YDDCAGGNQD LCVHGMCIDS DRVTPDEPKY
     KCICDAGWMS PPGSSACTAD VDECSLPNKP CSTNPPVQCF NTLGSFFCGA CPAGWQGNGY
     SCQDVNECET NNGGCSTSPV VPCLNTMGSF HCGQCPPGYE GDGKTCTQSD ICSTNNGGCY
     PLASCTSVPG SNIPTCTCPP GYVGNGFGPA GCTQIIDTCG TNNPCVNGQC ENTATGYVCH
     CDPGWTGRNC EQNVNECASN PCQNGGTCTD GINGYICTCT SQWTGPQCQT PQQECGGVLE
     GPSGTFSYPN TPGHDQYDHM VSCAWVVRTD ADKILRITFP FFDLEQSSTC SFDFLQIHDG
     ESASAYMLGK YCGTNSPAEL FSSHNSLYFW FRSDHIINKG GFTVAWQSQE PVCGGHLTNP
     YGDIKSPGYP GNYPPNRDCY WTIDVGPALI ITFAFGTLSL EHHPDCNYDY LEIRDGLLPE
     DPLLNRYCSS GSPPPLQTTG PAAWIHFHSD FVISDQGFHI TYTTSQTDPG CGGTYTESQG
     IIISPNWPNN YAHNKQCIYL IRLPRSERVA FNFTHMELEH HNGCELDYVE VRDGPGETAP
     LFGKYCGTTL PAPILSSANV LWIRFKSDSS VSLAGFRAVY EISCGGTLSG SGQIRTPLHP
     DPYPHNKMCE WVINQPTGYV VTLNFLTFDV EGNAACLFDY VEIRDGATSS SPLIGRYCGN
     QVPSTLQSTQ KHMYIAFSTD ASVSNHGFTA EYASVMEGCG DTLTAPTGSF TSPGHPTNYP
     HGANCSWHIA VAPGNIIRLS FTSFNLEYHV NCDFDYVEVY DNGTVQTGHL LGRYCGRSVP
     PSLTSTDNLM TVLFVTDSSM ATEGFAANYV SVDASTDCSA VFTTPTGVFT SPNYPNNYPN
     SRECIFRIIV EVNSQIMLNF TDFELEGGSN CVLDYVEIRD GGYETSPLIG RYCSTKAPPV
     VLSHSNRLWI KFRSDSSITY KGFSAHWDGT QTGCGGTLTT SVGSFTSPNY PLPYHPNAEC
     YWHIKISAGS KIQLSFGDFH LESSTGCSYD YLAVYDGNSS NALQLAKLCG NQLPAPINSS
     KEHLYVKLRT DSVISAGGFV ASYISNCQGI LIANQTNGVI ESQNFPNNYP VDARCSWTIQ
     VTMGNTINYT FTAFNLEGFL PGCIFDYLEL HDGPNAQAPL IGRFCADVPP PANTTSGTSL
     HIVFHSDFLD SRTGFRMLWY QNGCGGDLTG PAGSFNSPGY PNKYPDNREC VWYIQTSPGS
     SITITIHEFD IEYHPDCDYD MLEVYGGPDM SSPRLAQLCT TRPPNNPLHV SSTGNAVTVR
     FKSDAVGSGR GFNASWQETS GGCGGAVTAP RGEIHSPQFP NNYPNNADCS WVITVDPGHR
     ILFNFTDMDI EGHTTCDWDY VAIHDGPGEH SPLLVKVCGF STPDPVISTQ NVIYVRFRSD
     VSNNHKGFRA KFSEACGSTI MADDVGGDIA SPNYPSSYPN NQQCSWIIVA QEPFNHITLS
     FTDFELEMVN TNCSHDAVEI LDGNNNEAPV LGRYCGTDLP HPVTSFSNAL VVNFVSDSSV
     TKKGFRATYM ASTSGCGGNL HMESGAFNSP NYPGAYPPNI ECVWTIISSP GNRLQLSFIL
     FELQQSQGCN NDYLEIREGN STGTLVGRFC GNTLPSNYTS LIGHVLWIKF VSDSSVSGAG
     FRATFTHLYG NDVTGSSGQI ASPLYPRTYP NNADYRWTIT VSGDSYIEIR FLDIDIEDLF
     NCFYDQLKIF DGPNVHAYPL GVFCGLFRPQ PVRSSGSTMT LEFKSDFVIG GRGFLVEWTA
     VQSSGPLPTI APGACGGVLK PEDTPRFLFS PGWPNQYEPN LECTWVIRSP DSTVELNMLF
     MDIEDQAMCL YDSLVIRDGD TNLSPELAKL CGRELPGSLH STGDAMFLRF TSDSSINGRG
     FNASYSKGCG GLLHTDRGVL SSPHYPQNYK PSLNCNWHVM VTPGYRVSVT FLSPFQVQGF
     GTACSSGDYL ELKNGPDGNA PSLGGRLCGS SPPALTQTTD NHLHVHFVSD TSNEGIGFKL
     LFEAHSTACG GTIQLSDGDP PGYITSPNYP SNYPQNIDCV WIIMVPNGES VKLDFEDFYI
     EPNTGCSYDY LEVRDGVSSN ADLIAKLCGN TKPSTQHSTA SAMYLRFRTD GSITHKGFKA
     KYSIATCGGT YIGQSGTIKS PGYPDSNYPD NSNCEWYLEG PTGHYLTLSF MAFNLQSSVG
     CTSDYVEIRE YNASGHLLGK HCGNSLPGPV DTGDSFAYVK FVSDGSGSGT GFSLSFEASV
     EECGGDLNAP SGTISSPNYP NLYPHNRLCR WKITVPQGRR VTLTFNDLRL EDHNSCTFDY
     VEVINGFLSN SPRLQRFCGS VPAGTQVKSS GNTMTVVFVT DSSVSNGGFT ADYSSNEAAV
     CGGILSTPGN FTSPDYGVGN YSNNLNCEWL IQNPEHVNSS IVVILDDLHL EHHQTCEWDY
     LEFRLGDVNS ELLARFCGQT LPTVPIVVST SELWVHFLSD EAVVDLGFKA TYYFSDCGGL
     QSGVEGIIYS PGYPDNYPSP SRCAWLLEAP EGHTITLTFT YFQVEEHTQC SWDSVTVFNG
     GSPGAPIIGQ YCGHTSPGTI QSGSNKLSVV FLADHTVSKG GFVATWSVDS SGCGGVIHAD
     LGSFKSPNYP QNFPSNSECS WTIIAHEGNH LEMGFASEFQ IPDSSGHCQS SYIKVWAGDK
     QQNDALLATG CGSIAPPPII APFNIITARF QSTETPGKGF SASFFTRCGA NFSAPAGRVV
     SPNYPDHYPY NSNCDYRIDA GDQTVIVVTF RTFQLEAHST CSFDGVKIYK GSSESGNLLA
     TLCGNTIPGP FSTFGPMLIN FYSDSIINDN GFLAEYMAIP CGGVFNGTTG TIGSPAASVI
     HYHHNMNCTY HISLQDNRIV ELKFNSFHLE ASSTCAFDYV AVYDGPNTLA PLLGRFCGSV
     LPPTLKSLTN QMFLVFKTDA SVAAEGWRAT YRETLGTQQG CGGYLTSSSG MFGSPDIDMN
     GKYEPYLSCL WTIGVETNKA INLSFTTFEL EGGSSCPYDY VKIYDGDSVN YPLVGTFCGT
     VIPTAFVSAS NFLTVHFVTD GSVAFRGFNA TYSAVDRICG GIYNATTTAQ TITSPFYPNA
     YPSFTFCRWV LDAPPQEAVK IIVQQFHLQP SQSCSSNFLE MKDWPVGDYG QAHKFCGSDS
     HIPDFYSYDR TMHLTFQSDT FFTGNGFSLT YQVAGCSRVY EQSYGYLKSP GWPAVYPHDM
     DCTIVLRSPQ NSSISLFFDS FDVESHSSCN FDYLEVRNGS TATAPLLGKH CGNTLPNPIF
     PKSNELFLHF HSDFSATRNG FEITWTSSPQ GCGGGLYGDH GSFTSPDYPA TYPNGTHCEW
     GIRAPSGRVV MVTFNQISID DPGDCQNNYL KLYDGPDASS PPVGPYCGTE TNIAPFRASS
     HQVFIVFHAQ SVVLPSGFRL TWSS
//
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