ID W5UG01_ICTPU Unreviewed; 285 AA.
AC W5UG01;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Hairy-related 9 isoform X1 {ECO:0000313|RefSeq:XP_017341825.1};
DE SubName: Full=Transcription factor HES-4-B {ECO:0000313|EMBL:AHH38612.1};
GN Name=hes4-b {ECO:0000313|EMBL:AHH38612.1};
GN Synonyms=her9 {ECO:0000313|RefSeq:XP_017341825.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH38612.1};
RN [1] {ECO:0000313|EMBL:AHH38612.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH38612.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017341825.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017341825.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JT409272; AHH38612.1; -; mRNA.
DR RefSeq; XP_017341825.1; XM_017486336.3.
DR STRING; 7998.ENSIPUP00000031175; -.
DR Ensembl; ENSIPUT00000032423; ENSIPUP00000031175; ENSIPUG00000021012.
DR GeneID; 108275484; -.
DR KEGG; ipu:108275484; -.
DR CTD; 140613; -.
DR OMA; EDRCEPV; -.
DR OrthoDB; 2907677at2759; -.
DR Proteomes; UP000221080; Chromosome 15.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11459; bHLH-O_HES1_4; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF136; TRANSCRIPTION FACTOR HES-4; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 34..91
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 110..143
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 285 AA; 30266 MW; 1D1CB2C67342ACDA CRC64;
MPADTMEKQT ASPIAGAPAS GTHTPDKPKN ASEHRKSSKP IMEKRRRARI NESLGQLKTL
ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRVQMTAAM STDTAVLSKY RAGFSECMNE
VTRFLSTCEG VNTEVRSRLL NHLSVCLGQM MALNYPPTAP AQHPHLAQPL NVQVPSSAVS
SKLSPSEVVP SKVFGGFQLV PATDGQFAFL IPNPAFASAT TPVIPLYANA GVPVAVSASP
VHASSAPPAV SPVQGMTSFA GVSQAASPVG VSAGPESSEP VWRPW
//
