ID W5UHQ2_ICTPU Unreviewed; 380 AA.
AC W5UHQ2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
GN Name=tgfb1 {ECO:0000313|EMBL:AHH39197.1};
GN Synonyms=tgfb1b {ECO:0000313|RefSeq:XP_017349101.1,
GN ECO:0000313|RefSeq:XP_017349102.1, ECO:0000313|RefSeq:XP_017349103.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH39197.1};
RN [1] {ECO:0000313|EMBL:AHH39197.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH39197.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017349101.1, ECO:0000313|RefSeq:XP_017349102.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017349101.1,
RC ECO:0000313|RefSeq:XP_017349102.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JT410814; AHH39197.1; -; mRNA.
DR EMBL; JT413898; AHH40424.1; -; mRNA.
DR RefSeq; XP_017349101.1; XM_017493612.3.
DR RefSeq; XP_017349102.1; XM_017493613.3.
DR RefSeq; XP_017349103.1; XM_017493614.3.
DR STRING; 7998.ENSIPUP00000003544; -.
DR Ensembl; ENSIPUT00000003718; ENSIPUP00000003544; ENSIPUG00000002511.
DR GeneID; 108279384; -.
DR KEGG; ipu:108279384; -.
DR CTD; 563884; -.
DR OMA; LALEYMC; -.
DR OrthoDB; 5390486at2759; -.
DR Proteomes; UP000221080; Chromosome 18.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR CDD; cd19384; TGF_beta_TGFB1; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR016319; TGF-beta.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF125; TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF001787; TGF-beta; 1.
DR PRINTS; PR01423; TGFBETA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001787};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT CHAIN 23..380
FT /note="Transforming growth factor beta"
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT /id="PRO_5013540258"
FT DOMAIN 265..380
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT DISULFID 283..346
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 312..377
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 316..379
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 345
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ SEQUENCE 380 AA; 43262 MW; EA7363654889B34A CRC64;
MRAQSLLLAL LCLMGCVGYC GTLSTCKPLN LELVKRKRIE AIRGQILSKL QLAKEPEDDD
EGEEDEVPAE VLSVYNSTVD LSEELMQNTK HVDSFAAEEE AYYAKEVHKF NMTRIMNKMV
MLFDVSAMKG VLGSNRIVSQ AELRLLIRDP TIAPGNQQRL ELYEGDGDKA QYLNSQFITS
EFNSKWISFD VTQTVKNWLK NPEKEKALEV KLHCGCGEKE KKMPFHISGI YSERGDKEAL
LAKMTKPYIL VMSLPADRVH EVSSRRKRQA TGDADCSEQS DICCVRRLYI DFRKDLGWKW
IHQPSGYYAN YCIGSCSFVW NTENKYSQVM ALYKHHNPGA SAQPCCVPQV LEPLPILYYV
GRQHKVEQLS NMIVKTCKCS
//
