ID W5UI28_ICTPU Unreviewed; 615 AA.
AC W5UI28;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Kelch-like protein 21 {ECO:0000256|ARBA:ARBA00023877};
GN Name=klhl21 {ECO:0000313|EMBL:AHH41747.1,
GN ECO:0000313|RefSeq:XP_017343651.1, ECO:0000313|RefSeq:XP_017343652.1,
GN ECO:0000313|RefSeq:XP_017343653.1, ECO:0000313|RefSeq:XP_053542403.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH41747.1};
RN [1] {ECO:0000313|EMBL:AHH41747.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH41747.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017343651.1, ECO:0000313|RefSeq:XP_017343652.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017343651.1,
RC ECO:0000313|RefSeq:XP_017343652.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
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DR EMBL; JT415574; AHH41747.1; -; mRNA.
DR RefSeq; XP_017343651.1; XM_017488162.3.
DR RefSeq; XP_017343652.1; XM_017488163.3.
DR RefSeq; XP_017343653.1; XM_017488164.3.
DR RefSeq; XP_053542403.1; XM_053686428.1.
DR STRING; 7998.ENSIPUP00000032862; -.
DR Ensembl; ENSIPUT00000034156; ENSIPUP00000032862; ENSIPUG00000022067.
DR Ensembl; ENSIPUT00000034163; ENSIPUP00000032869; ENSIPUG00000022067.
DR GeneID; 108276467; -.
DR KEGG; ipu:108276467; -.
DR CTD; 9903; -.
DR OrthoDB; 5472491at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000221080; Chromosome 15.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18460; BACK_KLHL21; 1.
DR CDD; cd18250; BTB_POZ_KLHL21; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030577; BTB/POZ_KLHL21.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR047069; KLHL21_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF255; KELCH-LIKE PROTEIN 21; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR Pfam; PF13964; Kelch_6; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 38..105
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT COILED 585..612
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 615 AA; 69699 MW; 9A46EA82967AB05D CRC64;
MEKPVLQTQH SVLPFFDTAH AVNLLRGIHE LRAERKFFDV TLCAEGKEFH CHRTVLAAAS
MYFRAMFAGT LRESAMDRVA LHEVSAELLG LLVDFCYTGR VTVTCDNVDV LLKAADLFQF
PSVKAACCAF LEQRLDVSNC LEIQDFAEAY ACSELATSAR RFALNNIMEL AKGQEFERLP
WKRLLELMSD DGLRVDKEET AYQIAARWVK ADPRRGLQYW PELLQQVRLP FVRRFFLLAR
VESDPLVYLT PECLRLVGEA RSFQSGEYDR HDRPCQRMRP RPSTGLAEIL VVVGGCDQDC
DELVTVDCFN PQTGQWRYLA EFPDHLGGGY SIAALGNDMY VTGGSDGSRL YDGVWRYNSS
VNEWTEVSPM LKAREYHSSC VLKGQLYVVA SDSTERYDHA LDCWEPLASM LHPMDNCSTT
TCGGRLYAIG SLTGEDTMAI QCYDADTNRW NLVNCGQMPP WSFAPKSVTL NGLIYFVRDD
SAEIDTYDPQ KNEWDKISPM NQVHVGGSVA VLGGRLYVSG GYDNTFELSD VVEVYDPGAR
SWNLAGRLPQ PTFWHGSVSI FRQFMPHVPS TFEPVDIPEA DDIHLHRHHR HHQALQELNN
ELNQNHRNRE VNPAH
//
