ID W5UJ24_ICTPU Unreviewed; 381 AA.
AC W5UJ24;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
GN Name=Nck1 {ECO:0000313|EMBL:AHH41991.1};
GN Synonyms=nck1b {ECO:0000313|RefSeq:XP_017336359.1,
GN ECO:0000313|RefSeq:XP_017336367.1, ECO:0000313|RefSeq:XP_017336379.1,
GN ECO:0000313|RefSeq:XP_017336385.1, ECO:0000313|RefSeq:XP_017336393.1,
GN ECO:0000313|RefSeq:XP_047014415.1, ECO:0000313|RefSeq:XP_053540006.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH41991.1};
RN [1] {ECO:0000313|EMBL:AHH41991.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH41991.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017336359.1, ECO:0000313|RefSeq:XP_017336367.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017336359.1,
RC ECO:0000313|RefSeq:XP_017336367.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
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DR EMBL; JT416264; AHH41991.1; -; mRNA.
DR RefSeq; XP_017336359.1; XM_017480870.3.
DR RefSeq; XP_017336367.1; XM_017480878.3.
DR RefSeq; XP_017336373.1; XM_017480884.1.
DR RefSeq; XP_017336379.1; XM_017480890.3.
DR RefSeq; XP_017336385.1; XM_017480896.3.
DR RefSeq; XP_017336393.1; XM_017480904.3.
DR RefSeq; XP_017336402.1; XM_017480913.1.
DR RefSeq; XP_047014415.1; XM_047158459.2.
DR RefSeq; XP_053540006.1; XM_053684031.1.
DR STRING; 7998.ENSIPUP00000001267; -.
DR Ensembl; ENSIPUT00000001336; ENSIPUP00000001267; ENSIPUG00000000905.
DR GeneID; 108272450; -.
DR KEGG; ipu:108272450; -.
DR CTD; 100334953; -.
DR OMA; ADTDMST; -.
DR OrthoDB; 25798at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd11900; SH3_Nck1_1; 1.
DR CDD; cd11901; SH3_Nck1_2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR017304; NCK.
DR InterPro; IPR035562; Nck1_SH3_1.
DR InterPro; IPR035564; Nck1_SH3_2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF16; CYTOPLASMIC PROTEIN NCK1; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 3.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT DOMAIN 2..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 107..166
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 191..253
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 284..378
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 381 AA; 43162 MW; 0F64ED831778FD7A CRC64;
MTEEVIVIAK FDYMAQQDQE LDIKKNERLW LLDDSKSWWR VRNATNKTGF VPSNYVERKN
SARKASIVKN LKDTLGIGKV KRKTGMRDTA SNAEADFYPD NGERLYDLNL PALVKFNYTA
EREDELSLVK GTRVIVMEKC SDGWWRGSYS GRSGWFPSNY VTEDADGSAS NDMMGLSEKL
AAVVHSANGN RVLHTVQALY PFSSANDEEL NFEKGEMMDV LEKPENDPEW WKCRKADGQV
GLVPKNYVTI LQESQNSGSM AGPPTPDFDY IEPSGSGRFA GKEWYYGKVT RHQAEMALNQ
RGTEGDFLIR DSESSPNDFS ISLKAQTKNK HFKVQLKDNL YCIGQRKFGS MEELVEHYKK
APIFTSEQGD KLYLIKALAA S
//
