ID W5UJ36_ICTPU Unreviewed; 252 AA.
AC W5UJ36;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Sesquipedalian {ECO:0000256|RuleBase:RU369082};
DE Short=Ses {ECO:0000256|RuleBase:RU369082};
DE AltName: Full=PH domain-containing endocytic trafficking adaptor {ECO:0000256|RuleBase:RU369082};
GN Name=Fam109a {ECO:0000313|EMBL:AHH42087.1};
GN Synonyms=pheta1 {ECO:0000313|RefSeq:XP_017307153.1,
GN ECO:0000313|RefSeq:XP_017307155.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH42087.1};
RN [1] {ECO:0000313|EMBL:AHH42087.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH42087.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017307153.1, ECO:0000313|RefSeq:XP_017307155.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017307153.1,
RC ECO:0000313|RefSeq:XP_017307155.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|RuleBase:RU369082}.
CC Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus,
CC trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family.
CC {ECO:0000256|RuleBase:RU369082}.
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DR EMBL; JT416577; AHH42087.1; -; mRNA.
DR RefSeq; XP_017307153.1; XM_017451664.3.
DR RefSeq; XP_017307154.1; XM_017451665.1.
DR RefSeq; XP_017307155.1; XM_017451666.3.
DR RefSeq; XP_017307157.1; XM_017451668.1.
DR STRING; 7998.ENSIPUP00000034562; -.
DR Ensembl; ENSIPUT00000035918; ENSIPUP00000034562; ENSIPUG00000023218.
DR GeneID; 108255586; -.
DR KEGG; ipu:108255586; -.
DR CTD; 144717; -.
DR OMA; WELQGPT; -.
DR OrthoDB; 5483476at2759; -.
DR Proteomes; UP000221080; Chromosome 22.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0007032; P:endosome organization; IEA:UniProtKB-UniRule.
DR GO; GO:0001881; P:receptor recycling; IEA:UniProtKB-UniRule.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:UniProtKB-UniRule.
DR CDD; cd13288; PH_Ses; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR PANTHER; PTHR22902:SF15; SESQUIPEDALIAN-2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU369082};
KW Endosome {ECO:0000256|RuleBase:RU369082};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369082};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369082}.
FT DOMAIN 17..112
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 129..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 27958 MW; 95B5364FDB8DD1AC CRC64;
MKLNERSVVH YATCGVPPDK SGFLMKKSER SGTFHRRWCV LKANLLFLFE ERGRREPVGL
VVLEGCTVEL CESERVDFAF AVRFGTSHMH TLAADTQAEM EDWAKALARA SFQYLRLVVR
ELEKQLEEAQ KRHEDGAAGG GEESAALRPD LTGRENGISW SEPPQTDELG IPGRDNSVSW
NKPTAANGVA WESECGVKAR PPPVPPRRKS PPEMGVAHGG VGVSPGTTCF SKLHDWYGKE
VAQIRSEWLQ SQ
//
