ID W5UKZ1_ICTPU Unreviewed; 520 AA.
AC W5UKZ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
GN Name=USP3 {ECO:0000313|EMBL:AHH42666.1};
GN Synonyms=usp3 {ECO:0000313|RefSeq:XP_017341233.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH42666.1};
RN [1] {ECO:0000313|EMBL:AHH42666.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH42666.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017341233.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017341233.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707,
CC ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
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DR EMBL; JT418240; AHH42666.1; -; mRNA.
DR RefSeq; XP_017341233.1; XM_017485744.3.
DR STRING; 7998.ENSIPUP00000032292; -.
DR Ensembl; ENSIPUT00000033568; ENSIPUP00000032292; ENSIPUG00000021688.
DR GeneID; 108275133; -.
DR CTD; 9960; -.
DR OMA; AGKRIYN; -.
DR OrthoDB; 227085at2759; -.
DR Proteomes; UP000221080; Chromosome 14.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF19; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366025};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT DOMAIN 1..119
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT DOMAIN 157..509
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 120..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 58400 MW; F290CDA09C94FD71 CRC64;
MECPHLSSTV CVAMDPTRFP HGSPSSWCCS VCRSNKSPWV CLTCLNVHCG RYVNGHAKKH
FEEVHCSATG QKKTEKFQQH SVCMDCSSYS TFCYRCDDFV VNDTKLGQVQ RVREHLQSLE
NSVINSDRPR KRKLSGSSSP DLRMSADGEG PPARSATGLR NLGNTCFMNA ILQSLGNIPE
FSCYFKDLPA VALRSGKTAG RRMYHTRSQG DSSVSLVEEL RKTLCSLWQG SQTAFSPDAL
FYVIWKIMPS FRGYQQQDAH EFLRYLLDHL HRELQGSKNG LPGPSLLPDI PNLNSGSKCS
INGTPTMVTA VFGGVLHNEV NCLICGTESK KFDPFLDLSL DIPSQFRVKR TKDQEPGPTC
TLGDCLSSFT DLEQLDETEL YMCHKCKKRQ KSTKKFWIQK LPKVLCLHLK RFHWTAFLRN
KVDTYVEFPL RGLDLKCYLL ESENSLPESC LYDLAAVVVH HGSGVGSGHY TAYGLHEGCW
YHFNDSTVTV VSEETVAKAK AYILFYTEQD NTGSLTKPKL
//
