ID W5UMP6_ICTPU Unreviewed; 407 AA.
AC W5UMP6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=G/T mismatch-specific thymine DNA glycosylase {ECO:0000313|EMBL:AHH40947.1, ECO:0000313|RefSeq:XP_017330680.1, ECO:0000313|RefSeq:XP_017330681.1};
GN Name=Tdg {ECO:0000313|EMBL:AHH40947.1};
GN Synonyms=tdg.2 {ECO:0000313|RefSeq:XP_017330680.1,
GN ECO:0000313|RefSeq:XP_017330681.1, ECO:0000313|RefSeq:XP_053538121.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH40947.1};
RN [1] {ECO:0000313|EMBL:AHH40947.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH40947.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017330680.1, ECO:0000313|RefSeq:XP_017330681.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017330680.1,
RC ECO:0000313|RefSeq:XP_017330681.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JT415187; AHH40947.1; -; mRNA.
DR RefSeq; XP_017330680.1; XM_017475191.3.
DR RefSeq; XP_017330681.1; XM_017475192.3.
DR RefSeq; XP_053538121.1; XM_053682146.1.
DR STRING; 7998.ENSIPUP00000011298; -.
DR Ensembl; ENSIPUT00000011779; ENSIPUP00000011298; ENSIPUG00000007686.
DR GeneID; 108269360; -.
DR KEGG; ipu:108269360; -.
DR CTD; 558951; -.
DR OMA; PEYEETC; -.
DR OrthoDB; 5318912at2759; -.
DR Proteomes; UP000221080; Chromosome 8.
DR GO; GO:0000700; F:mismatch base pair DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006285; P:base-excision repair, AP site formation; IEA:InterPro.
DR CDD; cd10028; UDG-F2_TDG_MUG; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 1.
DR InterPro; IPR015637; MUG/TDG.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR12159; G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR12159:SF9; G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 133..283
FT /note="Uracil-DNA glycosylase-like"
FT /evidence="ECO:0000259|Pfam:PF03167"
FT REGION 69..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 46857 MW; 2318A42CE7C7E253 CRC64;
MEEKQFESQR QRMDSYQHWY HTTQQQFQPE PVPQYSQMVN VPYYQQDVKE YTVMNELSVH
EDPAQISPLH QLPVQPPALP STPEKGKKRG RPPKQGKNDQ TDAEVTVKKA KRTLDRFNGM
SVEEVMAKKL PDVITYNLDI LIIGINPGLL SAYKGRHYPN PGNHFWKCLF LSGLTDEQLN
YMHDQTLPEQ YGIGFTNMVE RTTPGSKDLS NKEIREGGKQ LLEKLQKYRP RIAAFNGKCI
YETFCKEIFG VKAKNLEFGL QPYKVPETET VCYLMPSSSP RCAQFPRAQD KVHFYIKLKE
LRDQLKGVVQ NREIQETEYT FDLVLAKEDA KRMSIKEEQH DPGYEESSTS ATLQTCSFYP
ANEQGAAHSE PSLALGQVGS NQWTMQPFAD QIPDIRYSSN NETSQYF
//
