ID W5UQB8_ICTPU Unreviewed; 1028 AA.
AC W5UQB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D, like isoform X4 {ECO:0000313|RefSeq:XP_053534198.1};
DE SubName: Full=Semaphorin-6D {ECO:0000313|EMBL:AHH41758.1};
GN Name=SEMA6D {ECO:0000313|EMBL:AHH41758.1};
GN Synonyms=sema6dl {ECO:0000313|RefSeq:XP_053534198.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH41758.1};
RN [1] {ECO:0000313|EMBL:AHH41758.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH41758.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_053534198.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_053534198.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; JT415601; AHH41758.1; -; mRNA.
DR RefSeq; XP_017321143.1; XM_017465654.1.
DR RefSeq; XP_053534198.1; XM_053678223.1.
DR Ensembl; ENSIPUT00000028454; ENSIPUP00000027341; ENSIPUG00000018402.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000221080; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_053534198.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1028
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013540388"
FT TRANSMEM 638..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..510
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 573..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..594
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 114752 MW; 0093DF5E616842DE CRC64;
MWCVMFPNLL LLLVRTHAIS FPEDTTALDI VDRHYSRQYP VFRGRPSGNE SQHRLDFQLM
TRIQDTLFIA GRDQVYLVSL RESYRNDITP YRKLTWRSGQ ADRETCALKG KHRDECHNFI
KVLVPRNDDL VFICGTNGFN PMCRYYRLDN LEFDGEEISG LARCPFDAKQ TNVALFSDGK
LYSATVADFL ASDAVIYRSM GDGSALRTIK YDSKWLKEPH FLHAVDYGNY VYFFFREIAA
EHNNLGRVVY SRVARVCKSD VGGSQRVLEK HWTSFVKARL NCSVPGESFF YFDVLQSLTD
IININGVPSV VGVFTTQLNS IPGSAVCAFS MPDIEKVFEG RFKEQKTPDS VWTPVPEDRL
PSLRPGCCAG HGSAESYKSS VEFPDETLQF IKLHPLMDAA VPSIRDEPWV TKTRVRYRLT
ALAVDNAAGP YKNYTVVFIG SEAGVVLKVL AKTAVFSLNE SVLLEEIDVF NQAKCLSNSE
DDRRVLSFHL DKDTHTLYVA FSSCVVRIPL SRCERHRTCH KSCIASRDPY CGWTSHGACE
RIPAGVDSGF EQDVEFGDTG RLGDCHAEQN PVLSVTPSSA SEPPPPPHTP PSLPPQLLDT
RKSVLRDSSE SSRSFESVME GVWEIQSADS NQLVHMNILI TCVFAAFLLG AFIAGAVVYC
YRDVFLHKKT RRIHKVPHSK DEESAPSRTD STGSFTKLND LFESPVKEFP NAMEEARIYF
SGDKDEKNPE FKTVIISRQN PELAALPTPE STPVLHQKGL QPNKNQWEKA QGKTCVSRKE
SPPKSPQNPN IPSAVVLPNA THEKMVPSSD TGSVKSVHKE RRRSVDARNT LNELLKHLNE
ANEVETINVN PKAIMADTPR PRQHLVLEPM GNLAEIPPKV PSREASLYSP TSYSPPSSYS
ASSYSPSSSL PRHSPTKRVD VPSVPTSPTG QMGTLDRQRF HRIGSTHRHA GSSSAMLTRH
SSFNRGALAP PTPPSRMDSQ GISRQHSYSG YGSLPRTSVK RTASLKPDVP PKPGGFVPQT
RPVNKYSY
//
