ID W5VZ06_9PSEU Unreviewed; 312 AA.
AC W5VZ06;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Daunorubicin/doxorubicin resistance ATP-binding protein DrrA {ECO:0000313|EMBL:AHH94133.1};
DE EC=3.6.3.- {ECO:0000313|EMBL:AHH94133.1};
GN ORFNames=KALB_759 {ECO:0000313|EMBL:AHH94133.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH94133.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH94133.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH94133.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
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DR EMBL; CP007155; AHH94133.1; -; Genomic_DNA.
DR RefSeq; WP_025354394.1; NZ_CP007155.1.
DR AlphaFoldDB; W5VZ06; -.
DR STRING; 1449976.KALB_759; -.
DR KEGG; kal:KALB_759; -.
DR PATRIC; fig|1449976.3.peg.763; -.
DR eggNOG; COG1131; Bacteria.
DR HOGENOM; CLU_000604_1_2_11; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AHH94133.1};
KW Hydrolase {ECO:0000313|EMBL:AHH94133.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..233
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 312 AA; 33026 MW; BCAC20722FFF40E7 CRC64;
MAVVAEGLRK QYGDKMALDG FDLTVAEGTV CGLLGPNGAG KTTAVRILAT LLRPDGGRAR
VAGLDLGTDA AAVRARIGLV GQQTAVDEVL SGWQNLVMFG RLHHLGAARA RARAAELLDR
FGLAEAGRKP VKQYSGGMRR RLDLAAGMIL APAVLYLDEP TTGLDPRARN EVWSAVRALV
AEGTTVLLTT QYLDEADQLA GQISVIDHGR VIAEGTPEQL KSRIGGDQLE LVLHEESDLP
AAAEVVRRVS GAAVEVDRDG RRVSAPVRDR VAALTDVVRA LAERGVPVQD IALRRPTLDE
VFLELTGSGV AA
//
