ID   W5VZK1_9PSEU            Unreviewed;       553 AA.
AC   W5VZK1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=KALB_539 {ECO:0000313|EMBL:AHH93915.1};
OS   Kutzneria albida DSM 43870.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Kutzneria.
OX   NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH93915.1, ECO:0000313|Proteomes:UP000019225};
RN   [1] {ECO:0000313|EMBL:AHH93915.1, ECO:0000313|Proteomes:UP000019225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH93915.1};
RX   PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA   Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA   Bechthold A., Kalinowski J., Luzhetskyy A.;
RT   "Complete genome sequence of producer of the glycopeptide antibiotic
RT   Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT   of Pseudonocardiaceae.";
RL   BMC Genomics 15:885-885(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
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DR   EMBL; CP007155; AHH93915.1; -; Genomic_DNA.
DR   RefSeq; WP_025354189.1; NZ_CP007155.1.
DR   AlphaFoldDB; W5VZK1; -.
DR   STRING; 1449976.KALB_539; -.
DR   KEGG; kal:KALB_539; -.
DR   PATRIC; fig|1449976.3.peg.548; -.
DR   eggNOG; COG1061; Bacteria.
DR   HOGENOM; CLU_008213_4_0_11; -.
DR   OrthoDB; 3713880at2; -.
DR   Proteomes; UP000019225; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|EMBL:AHH93915.1};
KW   Helicase {ECO:0000313|EMBL:AHH93915.1};
KW   Hydrolase {ECO:0000313|EMBL:AHH93915.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:AHH93915.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019225}.
FT   DOMAIN          190..344
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          399..546
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   553 AA;  61542 MW;  A1766E1BC876DEBB CRC64;
     MTDGPLIVQS DKTLLLEVDH PLAEETRTSI APFAELERAP EHVHTYRITP LALWNARAAG
     HDAEQVVDAL VRYSRYPVPQ PLLVDVVDTM ARFGRLQLVN HPAHGLTMLS LDRAVLEEVL
     RNKKISPMLG ERVDPDTVVV HPSERGRLKQ ALLKVGWPAE DLAGYVDGEA HPISLAEDGW
     QLREYQRLAA QAFWAGGSGV VVLPCGAGKT LVGAAAMAQA QATTLILVTN TVSGRQWKRE
     LVARTSLTED EIGEYSGERK EIRPVTIATY QVITRKTKGE YRHLELFDSR DWGLVVYDEV
     HLLPAPVFRM TADLQSRRRL GLTATLVRED GREGDVFSLI GPKRYDVPWR DIEAQGWIAP
     ADCVEVRVTL TDNERLTYAT AEPEERYKIC STANTKIPVV RAVLDRHKGE PTLVIGAYLD
     QLEELGAALD APVIQGSTKN KEREELFDAF RRGELRTLVV SKVANFSIDL PEASVAVQVS
     GTFGSRQEEA QRLGRLLRPK GDGRQAHFYS IVSRDTLDTD YAAHRQRFLA EQGYAYKIVD
     ADDLLGPALP EVD
//