ID W5W2X4_9PSEU Unreviewed; 5622 AA.
AC W5W2X4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Short-chain dehydrogenase/reductase SDR {ECO:0000313|EMBL:AHH94856.1};
GN ORFNames=KALB_1483 {ECO:0000313|EMBL:AHH94856.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH94856.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH94856.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH94856.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP007155; AHH94856.1; -; Genomic_DNA.
DR RefSeq; WP_025355073.1; NZ_CP007155.1.
DR STRING; 1449976.KALB_1483; -.
DR KEGG; kal:KALB_1483; -.
DR PATRIC; fig|1449976.3.peg.1492; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_8_11; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0050097; F:methylaspartate mutase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0019670; P:anaerobic glutamate catabolic process; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006396; Glu_mut_E.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF06368; Met_asp_mut_E; 1.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 466..543
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 561..983
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2111..2186
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2204..2628
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3762..3837
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3856..4280
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5464..5539
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5622 AA; 591680 MW; 76AD94A5B66CDF74 CRC64;
MTAAELVTGG FGEFVRRAAQ SGRLVVQPRM GMSDPAAMRA GLLSTKDARA TTVGTITLDS
YTRVGELHAV ETALRQGIGL NGYPIVSHPE ATTRSVLDGV ADEAFPVQVR HGSAVPLDIF
AAMMRAGLTA SEGGPVSYCL PYGRTPLYDS LRNWERSTEL FASLRSAQPH LESFGGCMMG
QLCPPSQLVA ISALEALFFH QHGMRCVSAS YAQGSNLAQD SEGVFALRRL CAELLPGVRW
HVVVYAHMGV YPTTPEGAYL LLGQAAELAR STGCERLIVK TVAESLRIPT VAENVAALEH
AGAVAERTPL LDKDLVNADT QTYAEARAFV DAVLDLDEDV GRALFLAFRR GYLDVPFCLH
PDNMGRSRSY LDTDGTLRWS ELGSMPLGGI VRTTSARPMG SSDLLRSLSF VRTKFDTQAL
MPSTNSQPVL LADQWSAPMS ESEDLVAGAE LTARLHTLSA PEQLRALVDL VAGAALAVLR
GIRPDAPAAL DPDRALRDAG FDSLSTVELR ARLVAETGLD LPVTVAFDHP TATALARYLR
AELLGLSEEV APVTAALAPS DDPIAVVGIG CRYPGGADSP ERFWQLLVEE RHVISPFPDD
RGWDLDSLFD PDPGQPGKTY AREGGFLAEA GEFDAEFFGI SPREAVAMDP QQRVVLETAW
EALERAGIDP ATLRGSQSGV FIGAEPQEYG PRLHEAPEGL DGYLLTGNAP SVVSGRVAYT
LGLEGPTLTV DTACSGSLVA LHLAVQSLRQ GECSLALAGG VAIMGSPGVF TSFSRQRGLA
ADGRCKAFAS AADGTGFAEG AGVFVLERLS DAQRNGHTVL ALLRGSAINQ DGASNGLTAP
NGPSQQRVIR QALANAGLTA QQVQVVEAHG TGTRLGDPIE AQALLATYGR DREQPLLLGS
VKSNIGHTQA AAGVAGVLKV IMAMRRGVLP RTLHVDAPTP HVDWSVGAVE LATETGPWPE
GVRRAGVSSF GVSGTNAHVI VEQAPQSEQD GQAVAPAVLP VVLSARTEEA LRAQARQLAE
ALPREEVTDF TYSLATSRST LERRAVLLGG DRDEVVRELR ALAEGTRASG TAVPGGLAVL
FTGQGSQRLA MGRELCEAFP VFADALVEAC GYLDLHLDRP LLDVLFGEDA DLLDQTGYAQ
PALFAVEVAL YRLVSSWGIR PDHLAGHSIG ELAAAHVAGV LTLADAALLV CARGRLMQAL
PTGGAMVAVR ATEQEVLPLL TDGVSIAAVN GPNSVVLSGI EESVLAVASQ FGKSRRLRTS
HAFHSALMEP MLAEFLRIAR VLTYSPPTIP IASSGDVTSP EYWVAHVRDA VRFGDRVSEL
VDQGVTTFLE LGPDAVLSAM GPESVADEAD VAFVPALRRD HAEAREAVAA LAQVHVRTGR
VDWAGYFAGT GARRVELPTY PFQRRRYWLP AGSSTVDAAG FGQVAADHPL LGAVLGLAAG
DGVVLTGRVS LRSHPWLADH VLSGSVLFPG TAFVELAVQA GDHVGCDLVE ELTLESPLVL
PSEGSVALQV VVGGEQSGRR TVDLYSGGGD GRWVRHATGL LGRTETAVSF DLTVWPPQGS
RAIDISALYE DMAGQGYGYG PVFRGLRAVW RRGAEVFAEV ALPEQEKPGA FALHPALLDA
VLHATDFAAE VPPGPEIRLP FAWTGVSVHS TGAAALRVRI TATGPEAVSL ELADPSGAPV
ASVESFVVRA VSPEQLRVTE RGGSLYEVRW QPITPQPAEL PADVQLVRIS SDAQDVPEAV
RQAVGQALEQ VQGSAPTVLI TRDNLSSAPV WGLVRSAQAE QPGRFVLVEL DEDPASEALL
PAAIASGEPE LALRAGQVLV PRLAPVDQST QDGEPFGPDS TVLITGGTGG LGGLVARHLV
AQYGVRQLVL TSRRGMDAPG AAELCAELDA TVTVLACDVA DRGALADLLA AHPVTAVVHA
AGVLDDGLIG SLTPERVDTV LRPKADAAWY LHELTRELDL TAFVLFSSAA GFVDGAGQGN
YAAANVFLNA LAEHRHAEGL PATSLAWGLW ADNAGMGANL DSLTLQRISR LGLDPLTAAE
SLALFDLAVR SGAPVTLPTR VDTRALLARA DGVPAILRGL VRTPSRRTAS GAGEVTFAHR
LAQLPPAERD RTLLELIRGK VAEVLGHDSA AAIDPGRAFT ELGFDSLAAV ELRNRLNTAT
GLRLPATLTF DYPTSTALTG HIAEALFGAE RRQPARTDLV AASEEPIAIV GIACRYPGGI
GSPEDLWRVV AEGVDVVSDF PVDRGWDVAD LYDPVPGMPG KTYAREGGFL HQAGDFDPDF
FGISPREATA MDPQQRLLLE TAWEVVERAG IDPISLRGSR TGVFAGVMYH DWATRLGEVA
EDLAGYLGNG SLASVVSGRI AYALGLEGPA VTVDTACSSS LVALHWAIQA LRSGECSLAL
AGGVTVMSTP DTFVDFSRQR GMAADGRCKS FAEAADGTGW SEGVGLLLVE RLSDARRNGH
EVLAVVRGSA VNQDGASNGL TAPNGPSQQR VIAQALASAG LHPSEVDLVE GHGTGTTLGD
PIEVQALLAT YGQDRDLPLW LGSIKSNMGH TQAAAGVAGI IKAVMAMRNG VLPRTLHVDE
PSHQVEWSAG NVRLLAEEQP WPELDRPRRA AVSSFGISGT NAHVILEQVP VLEPSARELE
PRVVPWIVSG RTPEALAAQV ARMSDVDADP LDVAYSLATT RAALPHRAAV AGTDRAELLR
GLADAQGAAA ESGAVAFLFT GQGAQRVGMG HELYEAFPVF AQAWDAVAAH LGDALRVDDE
QLLNQTGYAQ PALFAHEVAL YRLLESWGVT PDFVAGHSVG ELAAAHVAGV LSLTDACTLV
SARGRLMQAL PTGGAMVAVQ AGEHEIPSRD GVGIAAVNGP SSVVISGDEA GVLAIRAEFE
AMGRRTSRLR VSHAFHSPLM EPMLAEFARV AEGLSFAAPS IPMMGQVDSP EYWVRHVREA
VRFHDEIRAL EAHGVTRFVE IGPDGVLTGM AQDCVESELA ACIALQRKDR PQEHELVSGL
AKAFSHGVHV DWAAFFAGRG ARRVDLPTYA FQHRRYWINA TAAHGDVSAV GQVAINHPLL
GAAVSTPDSG GVVLTGRLSA QTQTWLADHE VRGSILFPGT GFVELAVQAG DQIGCGVVEE
LTIGAPLVVP ARGGVAVQVV VTEDRQFSVY SGGEGTWTRH ATGFLAEADT AQAFDLTTWP
PAGATPVEIG DTYRELAEQG YGYGPVFQGL RAVWRRGDEV FAEVALPEGS EADKYAMHPA
LLDATLHAMN FGEFLEPAKD EEITLPFAWR GVSLLAAGAA ALRVRMASAG TDAVTIQVAD
AAGAPVASVE SLLVRAMSAK TTSIASDALF RVDWIPVAAG ACTSTELDLP GAVVVPMITE
PTGDLAADTH AATQRALSLV QNWLAGESER LVVLTKGAMS ARGEAVTDLP AAAVWGLLRA
AQAEEPDRIT LLDVDEHGLP EQAVLAAIES GEPQLAVRGG EVFAPRLTRT ALAETPTAEL
DGTVLITGGT GSLGALVARH LVAQYGVRHL VLTSRRGSDA PGAAELCAEL SELGATATVV
ACDVADRAAL QAVLADVPAE HPLVGVVHTA GTLADSTIGA ITAEQLDSVL RPKVDAAWHL
HELTKDLDLA LFVLFSSSAG VVDGAGQGNY AAANTFLDAL AQHRRANGLP GVSLAWGLWN
QVGGMSGQLT DADLARLERS GILGITPEQG LDLFDAALSS DEPLLVPIRL NTTALRSRSA
LPSVLRGLVR TRSRRVVDAS LTTGGSTLAQ RLAALGEPER VQLLLDLVGT HVATVLGHEQ
AAAIDPRRAF RELGFDSLAS VELRNRLNSA TSLRLPATLV FDYPTPAALA EHIGDRLLGA
ESPVSAAVAV KSDVDEDPIV IVSMSCRFPG GVSSPEQLWE VVASGTDAVT AMPTNRGWDV
DGVYDPEPGK FGKTYTRHSG FLHEATDFDA EFFGISPREA LAMDPQQRLL LETSWEVFER
AGIDPSSLRG SRTGVFAGVL QTDYASRLTQ VPEDVEGYLT NGNMGSIASG RIAYVLGLEG
PALTIDTACS ASLVAMHMAA QSLRQGECSL ALTGGVTVMS TPDLLVDFSR QRGLSPDGRC
KAFAEAADGT GFAEGVGMLL LERLSDARRN GHPVLAVIKG SAINQDGASN GLTAPNGPSQ
QRVLSQALAN AGLSAAEVDV VEAHGTGTTL GDPIEAQALL ATYGQDRTRP LWLGSVKSNI
GHTQGAAGAA GVIKMVMAMR HATLPKTLHV DTPSTKVDWS AGAIELLTEA RPWEVNGHPR
RAGVSSFGIS GTNAHLIIEQ APDPVATEVQ STVHSSVPLV LSGRTETALR AQAARLADFL
RAEPTVNLAD VCFSLGTTRA ALEHRAVVVG GDHESVLAGL AALEGWESST DLVQGKASGG
SRLVFVFPGQ GSQWVGMAAE LLEQSPVFAE RLAECSAALS SFVDWNLLDV IRGAEGTPPF
ERVDVVQPAL WAVMVSLAAV WQSLGVRPAA VIGHSQGEIA AACVAGALSI EDAARVVALR
SKAIGEALAG RGGMVSVALP AEEVAGRLDE WGGQLSLAAV NGANSVVVSG TPEALDQLMS
QFGAEGVRVK KIAVDYASHS AQVETIRDRL RTDLGAITPR TGQVPFYSTV TSQWVDSVAL
DAEYWYENLR RTVQFDEAVR TLAGEGFGGF VESSPHPVLT IGIQETLDVL GRDAVVTGTL
RREEGGPHRL CLSLAELHVR GIAVDWSALL PNARRVDLPT YAFQRKRYWL DSGTTVADAS
GFGQVAAEHP LLGAVVPLPE SDGVVLTGRL SLHSHPWLAD HAVNGVAVFP GTGFVELAIR
AGDQVGCGRV EELTLEAPLV LPEQGAIGVQ VSLSAPDPEG RRALNVYSSA VDESWTRHAT
GLLAPAVQVD AHDLTVWPPE GASLITVDEP YRQLAERGYG YGPAFQGLRT VWRRGAEVFA
EVTLPATAEA AQFGLHPALL DAALHADTLF EDETRTVLPF AWNGVTLHAA GASALRVRLL
RDESGNISVD AADLTGAPVA TVSSLAVRVV SDAQLGSART TGADSLLRVE WTPITGSATE
PTGTWATVGE SVPDLDAAAG ADVVVLPVRA DSSDVPAAAH AATNRVLTSV QTVLSDERFA
TATLLVLTNG AVCATEDEDV SDLASAAVWG LIRAAQEENP DRFVLVDAES PTSQQLSAVL
ASGEPQVAIR GDALLAPRLA WAQGRAPADD WDAQSTVLIT GATGTLGRHF ARHLVERGVR
HLLLVSRSGG RFDELTELGA HVTVAACDAA DREALQRVLA AVPAEHPLSA VVHTAGVLDD
ATIASLTPEQ VEAVLRPKVD AAWNLHELTK DLTRFVLFSS AAGTFGGAGQ GNYAAANVFL
DALAAHRRAQ GLAATSLAWG FWAERSTMTG QLTEADVQRM TSAGVQPLST EHGLRLFDLA
LGGADPVLLP IQLDTTVLRE GEVPAILRGL VRPPARRAVQ VIEQDTELSL AERLTALSAP
ERERLVLDLV RGHIATVLRH EGAAAIEPNR EFAELGFDSL SALELRNRLS GMAGVRLPAT
LVFDYPSPAA VARHLLAELV DEEELAMSSL DADLARLEAA LAGVTPDDAQ HDRIAARLRA
LTTRWVESFG RAEQPVDDGA QLRSATADEL FSILDGELEA QN
//
