ID W5W5T0_9PSEU Unreviewed; 462 AA.
AC W5W5T0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=GntR family transcription regulator with aminotransferase domain-containing protein {ECO:0000313|EMBL:AHH95836.1};
GN ORFNames=KALB_2468 {ECO:0000313|EMBL:AHH95836.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH95836.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH95836.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH95836.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP007155; AHH95836.1; -; Genomic_DNA.
DR AlphaFoldDB; W5W5T0; -.
DR STRING; 1449976.KALB_2468; -.
DR KEGG; kal:KALB_2468; -.
DR PATRIC; fig|1449976.3.peg.2471; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_0_11; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AHH95836.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AHH95836.1}.
FT DOMAIN 1..64
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 462 AA; 48529 MW; 8E0FA96BCCA8B3D3 CRC64;
MANVIRVLRT TIAATAPGGR LPSVRRLMAT EHVSPMTVQR AMRSLAAEGL IEVQPGRGAF
VAAPGPSAVG APDLDWQSVA LGPRQVGDEA LPELLAVPRP ESVPLSSGYL EAALQPVAAL
GSALARAARR PAAWERGPVE GRADLRAWFA GAAGGAFRAG DMVVCPGGQS ALSTAFRALC
GSGDTVLVEA PTYLGAIAAA RNAGLDVVAV PADGDGVRTE LLATAFERTG ARLFYCQPLY
ANPHGAVLST ARRAEVLALA HRFSAFVLED DWARDLVVEG TPPPPLASQD EHGHVAYLRS
LTKSAAPGLR VAAIGARGAA GARLRAARAL NDFFVSGPLQ EAAVEFLSSP AWQRHRKDLR
QQLRTRRDAL LLALQRHLPQ LRPTAVPEGG LHVWVRLPEG VDDGALTTAA AARGVIVYPG
KPWYAVDPPA AHLRLTFGAA APEVLDEGVR RLATALADLR SR
//
