ID W5W7I3_9PSEU Unreviewed; 473 AA.
AC W5W7I3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=GntR family transcription regulator fused with aminotransferase {ECO:0000313|EMBL:AHH96511.1};
GN ORFNames=KALB_3144 {ECO:0000313|EMBL:AHH96511.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH96511.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH96511.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH96511.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP007155; AHH96511.1; -; Genomic_DNA.
DR RefSeq; WP_025356642.1; NZ_CP007155.1.
DR AlphaFoldDB; W5W7I3; -.
DR STRING; 1449976.KALB_3144; -.
DR KEGG; kal:KALB_3144; -.
DR PATRIC; fig|1449976.3.peg.3157; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_1_11; -.
DR OrthoDB; 5415143at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AHH96511.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AHH96511.1}.
FT DOMAIN 12..80
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 51458 MW; 24F3C632F659A129 CRC64;
MTDFHVSLDG RGDLADRIYR QLLAAILDGR LRAGERLPPS RELAQRLAVS RNTVTVAYDR
LTAEGFLVGR VGAGTFVGDV APGQAEARAA PSGTGIRPRE LWRTLRTPSS TSDAPPRYDF
RVGTPDARLF PLQVWRRLLA RELRHTTLDA FNYGDPAGHA GLRAAIARHV GVSRSVRSGA
EDVLVTQGAQ QALDLIGRVL VEPGEVVAVE EPGYWPARLL FQSLGARVAG VPVDGEGLDV
SAIPDAARLV YTTPSHQFPT GTAMSLARRT ALLDWARRRD AVIVEDDYDS EFRFGDRPLE
PLQSLDTAGR VLYVGSFSKT LLPMLRLGFV IAPASLRTAL RTAKQLSDWH GELPAQAALA
RFIADGLLGR QVRRASRIYA ARHELIVTTL HTEFADLLDL TPSAAGLHLC ARLRQGVSLD
FELARRRGVA AEDLAAYCGE QPAQRGLVLG YGAIEVDQIP EGLRLLHTCL ARA
//
