ID W5W7S2_9PSEU Unreviewed; 1333 AA.
AC W5W7S2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN ORFNames=KALB_3623 {ECO:0000313|EMBL:AHH96987.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH96987.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH96987.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH96987.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP007155; AHH96987.1; -; Genomic_DNA.
DR STRING; 1449976.KALB_3623; -.
DR KEGG; kal:KALB_3623; -.
DR PATRIC; fig|1449976.3.peg.3646; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_007528_0_0_11; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..1333
FT /note="Peptidase S8/S53 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004872949"
FT DOMAIN 256..516
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 42..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 265
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 297
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 472
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1333 AA; 138554 MW; CEAB3D215C618CA1 CRC64;
MLTGLVIPVE SAGRKRRTAF TAAVSLVIAS LLTFSTQPAA ALPGQPQRLG PTPPTSTATS
QPGDGSSYRV TLLTGDVVTY RTAAGQTSTT VDATTRSGPP PVFATSSTPE GYYVVPSDAQ
PYIAAGKVDR ELFNVRALIA QGLTDDASPT MPVLVRYGDA PQAPTLERRA RALPSTTRER
TLPAAESIAV SVQRTEAQGF WRSLTGTQQP GAGQPVLTES ASKVSLDRRF KASSIASSTG
TQQIGAPTAW AAGLTGTGVK IAVLDTGIDT THPDLAGRVG ESANFTGDPD AVDHFGHGTH
VASIIAGSGA ASGTTYRGVA GGAQLLNGKV LDNSGYGSES AVMAGMEWAV RQGARVVNMS
LGATTTDGND PISQLVDTLS ARSGALFVAA AGNDGAAVHV EAPAAASAAL AVGAVDSTDR
PAPFTSSGPR LGDAGAKPEI VAPGVDIIAA RAAGTSMGDP VDTNYTKLSG TSMATPFVAG
AAALIAQQHP DWQGPQIKSL LVSSAKDVGA PWYTQGSGRV DLTSALRSKV VATAAVSLGR
QSPSGSPKTQ AQQVSYTNLT GEPLSLKVTI GLTDWSGRPA PAGTVAVSTE ILTVPANGSA
SVTLTANPVK AASGPYGGTL SAAMPNGDPM SRTVVGLYVE PATYPVKVTL TDSLGAPATP
ATGQVSLVDE GYDWSNPKAN DPFRSPMIAV SLTDGSGTVQ MPKGTYSVLT SVMEQGISAR
RVDLFATAGT VVDRPSTIAL DARSTVAMEV NTQHPSDLRE RYVSVLRTLP GQTLPLGNGF
LSPPGWKVYV SPARAAAKGL ISTQDRLTLS EPVIGFSTPG LHPIYDPFAA PKLANAKQLP
LVAVGSGQQA DFAATDVRGK VAVVGLPVPD KSPSAVWQAA QQVAALAAQN GAAAVLSYVD
MPDAVPLVGL TSAPLPQLSL NGEEGRRLTS LVRTSRGSIS LQAKASPTYM DNLFLQDRNG
IPGSHVSQVD RNRLAEIKTA YHGDRPDLIL KKQWFAFPID VPSSMALAGT LVQGPSALTE
YVGPVDANTY WKRGVTEFAP DAAGAPDRMT GVSQISDDVY DRAGPKPVED WFEAPVRTGA
AETSAQRAPN STKLCSLCLS DTGTFAPALQ LMDSTRGHSV DPWQSGQYPT AVRMFRDGKQ
IPATSAWPLP VPMFTLPDTN SVYRLESEDV IPAKPVFGWP SAAVQRTATK MTSSWTFRPI
VPSGPLPSGY RCLDGWNRCA YQPLLQVHYD LGLDLNNRAP AGRDHSFEIT TRYHEAVATR
AQITALQVWY STDDGAKWQP ATVSAGHAGS YQVRVHNPAA SSGTGFVSLR VEAATADGGR
LIQTVQRAYG LTG
//
