ID W5W8A4_9PSEU Unreviewed; 541 AA.
AC W5W8A4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=KALB_3758 {ECO:0000313|EMBL:AHH97122.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH97122.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH97122.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH97122.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP007155; AHH97122.1; -; Genomic_DNA.
DR AlphaFoldDB; W5W8A4; -.
DR STRING; 1449976.KALB_3758; -.
DR KEGG; kal:KALB_3758; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_025328_0_0_11; -.
DR OrthoDB; 5241017at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..161
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 259..526
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 541 AA; 54819 MW; 0504092888C3AE70 CRC64;
MQSKTRRWIL GSGGAAVLAI IAVTGYLVFA PGPASRGGGG QQGVAPVKAT ADSVATSYLA
AFSGQSTEGA AALTDDRTTA SAALAKVYQG MGKASLTTSR DGGTETAQDG LSATARFGVK
WTLPGGGTFS YQDSMQLRRN GEDWQVHWSD ALVHPDLTKG QSLALRTETG KSSLLDRAGK
PVTSDSGIPA GVLQGVRQEV GEVNGTDGWR VVAVDSAGAD GRTLQEKKGS TPEQYTVTID
ARTQKAAQDA VSAQSGAAAV VALSPAGEFL AVATNSAYDA RNESPLTGLY TPGSTFKIVT
ATAALEQGQV SGGSTVSCPP TITIGQRTIP NDGNPPFGGG AAPDYSVSLR TAFALSCNTT
FSTLASKLDT SALPATARQL GIGVDFTIPG VTTNTGSIKP VSSPAEQIED GFGQGTDTTS
PFGLAVLAAT VQSGKLPTPT LIRGKQTQVT GQVPAPSPGV LAQVRQMMRD VCTTGTAKSL
AGFPGLAGKT GTAEVGAGQS KQAHGWFVGY REGLAFAVLM PDAGTSHTAV DTAGAFLRGL
G
//
