ID W5WIU4_9PSEU Unreviewed; 3725 AA.
AC W5WIU4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AHH98099.1};
GN ORFNames=KALB_4737 {ECO:0000313|EMBL:AHH98099.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH98099.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH98099.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH98099.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; CP007155; AHH98099.1; -; Genomic_DNA.
DR RefSeq; WP_025358132.1; NZ_CP007155.1.
DR STRING; 1449976.KALB_4737; -.
DR KEGG; kal:KALB_4737; -.
DR PATRIC; fig|1449976.3.peg.4769; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_224422_0_0_11; -.
DR OrthoDB; 5478077at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17651; A_NRPS_VisG_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR CDD; cd00610; OAT_like; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..78
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 94..500
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 968..1046
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2558..2633
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3625..3700
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3725 AA; 405454 MW; 95E5F453AA2A1564 CRC64;
MTPDQMESWL IDRIARHVGR AAADIDPDEP LASYGLSSRD AVGMIGELET VTARTLSPAL
IWEHPTIRQL SRHIADVPVP APAVEASEPP AGAQEPIAVV GVGCRFPGAD GPEEFWRLLA
DGVDAVAASP RRTQLPGAHG LLEDIETFDA EFFALSARET PYVDPQQRLL LEVAWRTLES
AGTPPDSLAG SQTGVFVGIS VGDYTRVQTN TPERLTEYSG TGSALSVAAN RMSYFFDFRG
PSVAVDTACS SSLVAVHMAC ESLRAGESTL VLAGGVNLIV LPEVTEILTK AGMMAPDGRC
KTFDAAADGY VRAEGCGLLA LKTLSAARRD GDQVLAVIRG SAVNHDGRSN GLAAPNGQAQ
REVIRSALHR AAITPAEVDY VEAHGTGTAL GDPIEIRALT DVLAEGRDAE EPVLVGSVKT
NIGHAESAAG IAGLIKVILM LRHRQVPPHL HLSRINPDVA AKPVRIPLRL SDWPRRLGAR
TAGVSGFGFG GSNAHVIVQE ATEEPATPDE VDGRTVHVLT LSARTESALD AARTAWGERL
RGATDVSVED ACVTANTGRQ HFTHRLAVVG GDRAQLADQL LRRSTSDVHN GIVRLGQSGK
LAFLFSGQGA QFADMARQLY TTNPWFRREL DQCDEVLGEY WGRSLSSVLF PDPADRGLLD
QTRYTQPALF AIECALARLW QSWGIEPDYL LGHSVGELAA ACVAGVFDLE QGLRLAAERG
RLVQELVPAG AMLAVFTEEQ AVRAMLDEWP GLAVAAVNGS RNVAVAGAST LVAAFAEVLA
ARGIDTRPLN STYPFHTPAM AAAGTAFGRA ARAVPHSSPR IPLVSDLDGR LFDAEHVLDA
SYWERHLTQP VRYADGIRLL AGLGCDTYLE VGPGRTLIGA GQREVTGRLW LASLRPTIDD
WAVLSDSLAQ LYVSGRPVDW AGHHRGQRAR KQPMPGHHFD RQRHWFPLPG DPHHERPAER
AEVPVLTAQP SRDVHTVLAE TVGRLLHHHG PVDPHASFLE LGADSMTLFQ TLQTVQETFQ
VRLPVSRLFE ELNTVDRLAA YITENAPKHV LDQLITPAPV PVAAQPRTAP APANGAAPDD
AVGQFLSVHE RVMAQAYELL QGRKTPLPPR PAEPQTQQTK QRETYVAFQQ TEAKRSGAWN
AEQHAFAEEF VRRFCARTAV SKQQAIQERA YHADVRHAPQ PHIDLRETRY PIAVTRSQGA
RMWDVDGNEY LDLTMGFGVN LFGHNESFIN EAITGQLDHG MQLGPHPLLA AEVAELVCEM
TGKQRAVFCN TGSEAVMVAV RLARAVSGRT KVALFAGSYH GSADPILARQ DPNGRTGDAA
PLAPGVPAAV GQDTLILPYG EDEALAMLRD HVHELAAVLV EPVQSRKPEL QPVEFLRQLR
EITAQAGVAL IFDEVITGFR VHPGGAQALF DVPADLAVYG KIIGGGLPIG MVAGNSEYLD
AIDGGAWGFG NTPYPQSVRT FFTGTFCKHP LALAASRAVL REMRRRGPGL HAELNQRVEG
MADRLNAMCR EAGVPIAVVN FGSLFRLRFP EEPMLSETVE LFHLMLVERG LYIWEGRNCF
LSTAHTDEDV DRIVSIFADT VNELRAHGFF PGSKAVADQP GGYPLTDMQR EFWLLNQIGP
EQARVCVETA LLELRGELRV DALRESLQDL VRRHDTLRTT FAADGSEQLV AHSLQLDVPV
LDFSADPAAR AQWLTAQTET TFDLTAAPLV RVAVLKIADD RHQLHVAAHH TVLDGWSFVV
LFNELEHLYN TRVSLGAERL APAPRYQEFV DRRLRYLSGE DAARDRAYWL NHFPNGVPTL
RLPTDRPRPP RVTYHGGQVP MVLGQDVATR LAKTARELGN TPFTILLGAY ALLLHRVTGD
QDVVIGVPIA LREDKGADRL VGNCGNMVPV RSRLTGAMTV ADFLTSLRQD LFAAHDHAAY
PFAELRTEML AGVDGTRAQL INTTFNLDNA VTAPQLDGLS ATLLTAESHY AKADIEVDMV
SMGDEIRAVF KYNADLFDEP TIRGHVATFA LLLDAFLTEA DQHAKRIPMI TAAASATLHQ
WEDGGTATIS DTTLHALFEE RVERAPDALA VLFEQEKVTC AELNARANQL ARLLADQGVA
QESVVGLMVP RSIDMVVAVL AVLKAGAAYL PIDIAYPDKR VKTIVSDARP RLVVTTSEIA
SRLGLDCPVV ALDEQPQAEY LTENLARTVT PANPAYVLYT SGSTGKPKGV VMSHESLVNL
FDWSHKDMAV EPGAVVAQFA SLGFDASAHE IFSALLYDKV LAVPTEEVRR DARKLAEWLE
LFGVGELHVP NLVLEAVCEA AEELGVVLPE LKVVAQAGEA LTPSDRVRRF FDAVEDRRLF
NHYGPSETHV VTTAKLAAEV ADWPVNAPIG RPISNTRSYV LDEEMQTVPP GVVGNLYAAG
VGLAHGYLNM PARTAEVFLP DPFGEPGTRM YRTGDLARWL PDGQLEFFGR ADRQVKVRGN
RVEPGEVELV LERQPGVSQA AVVGRGDVLV AYIVAATGSQ VDAAALRDAV RDSLPDYMVP
SLFVPLESLP LTQNGKLDTR ALPDTLEAAR VNQTEYLAPR TDTETTLAAI WADVLGVDRV
GVSDDFFLIG GHSLAVTRVI SKIRAELGSE VPIRWLFDAP TIAGLAALLD GPHTTSETRP
ELCPRVRPNE IPLSYAQSRL WFLNRLEGPN PTYNMALPVR LTGELDLAAL TAAVQDVVAR
HETLRTRFVE LDGQPTQQVL DSAEATVDVT VQRVDRDQVE QAVERACEYP FDLTTDLPLR
ICLFQVRQDE HVLVIVVHHI AGDAWSASPL AQDLGTAYAA RRTGTSPAWQ PLPVQYVDYT
LWQRELLGSE EDPGSVVSRQ LAFWRERLAG IPLEISLPVD RRRPAVASFR GDSVGFVVPA
EVHAGLARIA AEWGASLFMV VRAGLAVLLS RLGGGTDVVV GSPVAGRLDE AVADLVGFFV
NTLVLRVDVS GDPTFGELVG RVRDGDVGAL EHQDVPFERL VEVLNPERSL ARHPLFQVML
AFDNTSDFQT QLVDLDATEI PRGSTAAKVD LVFQMRERRG SDGTPAGIVS SLEYATDLFD
RSTIERITTY FLRALTAVVA EPDIRCGAID LLSPAEHKQL SESWTELARP VPVDTIPDLF
EAQVERTPDG VAVVCGTDQV TFRDLNDRAN QVAHHLRRYG LSNQSRVGVL MDRSTEMIAA
VIGIWKAGAS SVPLPSDMPV RRRDAIIAEA RVTHVLAHRR LAEDLDNLDA TTVLVNGNPK
LDNEPTDNSG VVVRPHDMLT TVFTSGSSGT PKGVMFEHHN LVSGFAAYDE TYRLRGRVTS
ILQMASEGFS VFTFDLVRAI LSGARLVLCP QDLLLRPAEL FDLMRRERVD CAEFVPAVIK
GLVAHLRSTG ERLDFIKVLI VASDTLYADE LATIKELTGP DCVVVNQYGM TECTIDSTFH
PARGHDSEYE RRNLIGKPFP NTVVYVLDES MRPVPQGVPG ELYVGGEGLS RGYLDRPDLT
AERFLPDPIT PLPGARLYRT GDLGRQLVDG SLELFGRADR QVKVRGNRVE PGEVELVLER
QPGVSQAAVV GRGDVLIAYI VAATGNEVDA AALRDAVRDS LPDYMVPSLF VPLESLPLTQ
NGKLDTKALP DTLEAARVNQ TEYLAPRTDT ETALAAIWAD VLGLDRVGVS DDFFLIGGHS
LLATTVLAAV RDHFKVEIPL RRLFENPTVA ALAREIADQL TQPDEVADEL DDLVTMVERS
VHTEQ
//