ID W5WNB6_9PSEU Unreviewed; 395 AA.
AC W5WNB6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN ORFNames=KALB_6279 {ECO:0000313|EMBL:AHH99639.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH99639.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH99639.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH99639.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP007155; AHH99639.1; -; Genomic_DNA.
DR RefSeq; WP_025359538.1; NZ_CP007155.1.
DR AlphaFoldDB; W5WNB6; -.
DR STRING; 1449976.KALB_6279; -.
DR KEGG; kal:KALB_6279; -.
DR PATRIC; fig|1449976.3.peg.6300; -.
DR eggNOG; COG0381; Bacteria.
DR HOGENOM; CLU_041674_1_0_11; -.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225}.
FT DOMAIN 30..371
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 395 AA; 42662 MW; 6DBF28AF6ABDA2C9 CRC64;
MMLPEVHLVC GTRPEAVKLA PVALELLSAG RIRPVLVASG QHPAMVRQAL AAFGLTPDVE
LSLHRETGEQ AELYSGLLPE LDGLWARHRP GAVLVQGDTA TTVAAALAAF WRRIPVVHLE
AGLRSHDIGS PFPEEANRRL VSVLAALHLP PTDRAARHLA DEGVPQDRTL VVGNTVVDAI
RTVSRRGRAF TEPALVEVER RARAGERRLV LVTVHRRENW GGPIASVLAS VRTLARRYPD
LDVVLPAHPN PVVSQQVREA LRDCPRVLVT EPLEYSDLAR LLGSCTLVLS DSGGIQEEAP
SFGVPVLVLR ESTERQEALD AGCALLVGTD EELILDAAHR ILSSPEVAAS MVSAGNPFGD
GQAARRTEEA LAVLLGLDTR LPDRFEPGQH RALLR
//
