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Database: UniProt
Entry: W5X2K7_BDEBC
LinkDB: W5X2K7_BDEBC
Original site: W5X2K7_BDEBC 
ID   W5X2K7_BDEBC            Unreviewed;       622 AA.
AC   W5X2K7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   26-FEB-2020, entry version 37.
DE   RecName: Full=DNA primase {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00993443};
DE            EC=2.7.7.- {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00993444};
GN   Name=dnaG {ECO:0000256|HAMAP-Rule:MF_00974};
GN   ORFNames=BDW_00875 {ECO:0000313|EMBL:AHI04685.1};
OS   Bdellovibrio bacteriovorus W.
OC   Bacteria; Proteobacteria; Oligoflexia; Bdellovibrionales;
OC   Bdellovibrionaceae; Bdellovibrio.
OX   NCBI_TaxID=765869 {ECO:0000313|EMBL:AHI04685.1, ECO:0000313|Proteomes:UP000019233};
RN   [1] {ECO:0000313|EMBL:AHI04685.1, ECO:0000313|Proteomes:UP000019233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W {ECO:0000313|EMBL:AHI04685.1,
RC   ECO:0000313|Proteomes:UP000019233};
RA   Mussa H.J., Iandolo J.J.;
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA polymerase that catalyzes the synthesis of short RNA
CC       molecules used as primers for DNA polymerase during DNA replication.
CC       {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811,
CC       ECO:0000256|SAAS:SAAS00709340}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00709317};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR002811,
CC         ECO:0000256|PIRSR:PIRSR002811-1};
CC       Note=Binds 1 zinc ion per monomer. {ECO:0000256|PIRNR:PIRNR002811,
CC       ECO:0000256|PIRSR:PIRSR002811-1};
CC   -!- SUBUNIT: Monomer. Interacts with DnaB. {ECO:0000256|HAMAP-
CC       Rule:MF_00974}.
CC   -!- SIMILARITY: Belongs to the DnaG primase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811,
CC       ECO:0000256|SAAS:SAAS00709351}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00974}.
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DR   EMBL; CP002190; AHI04685.1; -; Genomic_DNA.
DR   RefSeq; WP_025306970.1; NZ_CP002190.1.
DR   STRING; 765869.BDW_00875; -.
DR   EnsemblBacteria; AHI04685; AHI04685; BDW_00875.
DR   KEGG; bbw:BDW_00875; -.
DR   PATRIC; fig|765869.4.peg.175; -.
DR   HOGENOM; CLU_013501_3_3_7; -.
DR   KO; K02316; -.
DR   OrthoDB; 1071997at2; -.
DR   Proteomes; UP000019233; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003896; F:DNA primase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd03364; TOPRIM_DnaG_primases; 1.
DR   Gene3D; 3.90.580.10; -; 1.
DR   Gene3D; 3.90.980.10; -; 1.
DR   HAMAP; MF_00974; DNA_primase_DnaG; 1.
DR   InterPro; IPR013264; DNA_primase_core_N.
DR   InterPro; IPR037068; DNA_primase_core_N_sf.
DR   InterPro; IPR006295; DNA_primase_DnaG.
DR   InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR   InterPro; IPR030846; DnaG_bac.
DR   InterPro; IPR034151; TOPRIM_DnaG_bac.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR002694; Znf_CHC2.
DR   Pfam; PF08275; Toprim_N; 1.
DR   Pfam; PF01807; zf-CHC2; 1.
DR   PIRSF; PIRSF002811; DnaG; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SMART; SM00400; ZnF_CHCC; 1.
DR   TIGRFAMs; TIGR01391; dnaG; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00993445};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|SAAS:SAAS00709369};
KW   DNA-directed RNA polymerase {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00709327};
KW   Magnesium {ECO:0000256|SAAS:SAAS00709345};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR002811,
KW   ECO:0000256|PIRSR:PIRSR002811-1, ECO:0000256|SAAS:SAAS00709338};
KW   Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00709339};
KW   Primosome {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811,
KW   ECO:0000256|SAAS:SAAS00709304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019233};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00709341};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00974,
KW   ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|SAAS:SAAS00993442};
KW   Zinc {ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|PIRSR:PIRSR002811-1,
KW   ECO:0000256|SAAS:SAAS00709300};
KW   Zinc-finger {ECO:0000256|PIRSR:PIRSR002811-1,
KW   ECO:0000256|SAAS:SAAS00709301}.
FT   DOMAIN          264..347
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   ZN_FING         38..64
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002811-1"
SQ   SEQUENCE   622 AA;  70276 MW;  FB855BEA36819F1F CRC64;
     MRFNQEFIER VSEANNLVDI ISQYTQLKPA GRGLMGRCPF PDHVEKTPSF SVSELKQVYH
     CFGCHKSGNV FSFLRDYQGM NFPEAIEYLA TRASIALPEP EAQDPEADRA AEFRRQLMRA
     NKLASEFYIQ ALKTVSHDHP VKKYIASRGL SAEVIEAFGI GYADAEWDSL EKHLLAHKIP
     VAVAEEARLI KARTNKSGHF DLFRDRLMFP IHSPMGEAIA FGGRYLEKKE NEPKYLNSPE
     TPVFVKGRIM YGLTQTARYI RSEDSALIVE GYMDLVSLFQ VGIRNVVASM GTALTPDHGR
     LLKRMTKNVV ALFDGDAAGM EAAERSLAIL LASDLYPKGL TLPNGMDPDD YVKKYGAEAL
     KIEIERAPDL FVLILNRWME NYRGDASEKV QLADKLKPLF QVVPDQRLRD LYLAEAAQKM
     SVTLPWLRQA VGIQSSGYVY NQNRPQMTRT LPAQSAPSSA KPVEKTAEGS SVEMAKISLK
     AASKAEILLM GLVLKSRANF DHFERENILS SVSHEGVLKI LQKATDVYRQ DLNKFDKLTS
     LLVSYVDHPE YLFQKELQSE TNAGFDEESE MKLLRDCFKR VKENFLRDQA KKLARDLKSE
     PSSEKLEQIM NIQRSRISLN KG
//
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