ID   W6JUA6_9MICO            Unreviewed;       565 AA.
AC   W6JUA6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=3-oxosteroid 1-dehydrogenase {ECO:0000313|EMBL:CCH72111.1};
DE            EC=1.3.99.4 {ECO:0000313|EMBL:CCH72111.1};
GN   Name=ksdD {ECO:0000313|EMBL:CCH72111.1};
GN   ORFNames=BN11_1350016 {ECO:0000313|EMBL:CCH72111.1};
OS   Tetrasphaera australiensis Ben110.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC   Tetrasphaera.
OX   NCBI_TaxID=1193182 {ECO:0000313|EMBL:CCH72111.1, ECO:0000313|Proteomes:UP000035763};
RN   [1] {ECO:0000313|EMBL:CCH72111.1, ECO:0000313|Proteomes:UP000035763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ben110 {ECO:0000313|EMBL:CCH72111.1,
RC   ECO:0000313|Proteomes:UP000035763};
RX   PubMed=23178666; DOI=10.1038/ismej.2012.136;
RA   Kristiansen R., Nguyen H.T.T., Saunders A.M., Nielsen J.L., Wimmer R.,
RA   Le V.Q., McIlroy S.J., Petrovski S., Seviour R.J., Calteau A.,
RA   Nielsen K.L., Nielsen P.H.;
RT   "A metabolic model for members of the genus Tetrasphaera involved in
RT   enhanced biological phosphorus removal.";
RL   ISME J. 7:543-554(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCH72111.1}.
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DR   EMBL; CAJA01000041; CCH72111.1; -; Genomic_DNA.
DR   RefSeq; WP_048697214.1; NZ_HG764815.1.
DR   AlphaFoldDB; W6JUA6; -.
DR   STRING; 1193182.BN11_1350016; -.
DR   OrthoDB; 9813348at2; -.
DR   Proteomes; UP000035763; Unassembled WGS sequence.
DR   GO; GO:0047571; F:3-oxosteroid 1-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CCH72111.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035763}.
FT   DOMAIN          10..532
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
SQ   SEQUENCE   565 AA;  60013 MW;  B1F1417F58E01BFC CRC64;
     MSVTWHGTYD LVVAGTGAAA FAAAVTAADE GMTVLMLEST DRWGGSTAMS GGGLWLPNNP
     LMQRDRAGDS REEALTYLDA TVGDAGPGAS RHRKEAFVDG VGSFVSLAER LGMRFARAAA
     YPDYYPERPS GKIGRAIEHE PFDRRRIGQW WASSRGQDGV PLPVKTDDFW LLSRAWSSPD
     GMTRGARVVA RIAGSAARGH KKVGMGAALA CSFLEIAIAQ GTPVWLSSPV QDLIVEDDRV
     VGVRTIKDGK EIHVRATRGV VLGAGGFDHN AELRRRYQGV DGTASSGSSG NVGSTIALAE
     RVGAALDLMD DAWWGGSIPP SGPDKSAAFL VSERSMPHSI IVDGAGRRFA NESESYVDLG
     HHMLEHSREV TGRYWMITDA RHARKYLRSY ALDPRENKAR SAAGIAHSAH TIHDLADLTG
     LDPTALAETV ERFNANARTG IDHDFGRGNS AYDRYYGDPL SSPNPNLGTI EKAPFAAVEI
     VAGDLGTKGG IVTDGHARAL RANGTVIEGL YAAGNCSASV MGRTYPGPGS TLGPAAVFGH
     LAARHAAAQG WAPDDTQDVD RSRVE
//