ID W6KEI2_9TRYP Unreviewed; 3925 AA.
AC W6KEI2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=GSEM1_T00000406001 {ECO:0000313|EMBL:CCW59849.1};
OS Phytomonas sp. EM1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW59849.1, ECO:0000313|Proteomes:UP000027080};
RN [1] {ECO:0000313|EMBL:CCW59849.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW59849.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW59849.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW59849.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
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DR EMBL; HF955061; CCW59849.1; -; Genomic_DNA.
DR EnsemblProtists; CCW59849; CCW59849; GSEM1_T00000406001.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000027080; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT DOMAIN 569..706
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 848..1116
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1196..1363
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1562..1719
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3643..3688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1864..1891
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2028..2090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2348..2375
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3925 AA; 445882 MW; 6D8D25EB76481D78 CRC64;
MNDELSKVEV VYAVYEKWMA VLRRWNRCGW KDILLQDLET TTEEIAKETR ILGKQYGTLE
VFLPIQELIL NFQSSLPFLS KLKSPALKSR HWKELMRVTG RQFKYEQMSL NDLIAMELFR
FTDEVDTITL TAAREQNIET EIRNMREFWA AKDFILAKYE PRKGDVRCNV LTDLSTIQDA
VDDNTLKMQS IANVKWAQPF MDDVRMWENK LSMINEVIAI WVAVQKKWQY LESIFMGSED
IAVQLPKETA KFIDLDKKFV RIMNDTTASP NVIHVCNVSG RLEELSYIEE KLEECQKELS
NYLDSKRHLF PRFYFISDDE LLSILATSSA RAVQEHMLKL FDNCAALVFK SEFDETVCGV
DSQEGERLDF ANPVKTEGRP VEEWLQKVLE ESRSTLHDIL KAGVFYYPKM IRQKWLNEYL
GMVTLTGTKI FWTFEIENAF DLLKKGKKNA VKELQSKLSE QLFDLVGEID KDIDTQYRRK
INTLIIVDVH GRDIVDRFVR DSVIDAREFD WESQLRFYWE RATDTCVIRQ CTGYFNYGFE
YMGLNGRLVI TPLTDRCFMT LTQALTFYLG GAPGGPAGTG KTESVKDLAK AMAIQCVVFN
CGEGLDYKAM GTIFSGLSQT GSWGCFDEFN RIELPVLSVV SEQLRSIQAA LRAKQTEFLF
GDSMIRLVPT VGTFITMNPG YAGRVELPDN LKALFRPVVM VVPDMELIAE NMLFSEGFKT
ARELAKKMVT LYALAKGQLS KQYHYDWGLR ALKAVLVMAG RLKRGSPELQ EESVLMRAMR
DMNAPKFIAE DEPLFRGLIG DLFPGLDPTR VPQENLANAG AKILRARGFK TDAKQIDKVV
QLYETMQTRH TSMVVGPTGG GKSVVIDTLC KAQAELGLPT KSYVINPKAQ PTSLLYGYMD
PMTRNWSDGI FSNIFRSINC ATESASNERR YIIFDGDVDA KWVEDMNSVM DDNKLLTLPN
GERIRLRPQC SLLFEVGDLQ YASPATVSRV GMVFLDPVNL GWRPFMYSWR ITRPQDEQDT
LDELTEQFVQ PLIDFVLDGV CRNEITPPPK LVIPTTDLNM VKQLTTMLHT MSPGTTPLEP
RALQCVFILA CLWSFGALIK TQEDRLRFDV FLKKLSGWSL QDVGDNYLNR FVGSGSLPER
KTLYDYFFDL QDGRWKPWNV LVQPFSRAPN QKFSTLLVST VDTERNMWLL DKIVLNRTPV
LLVGESGTAK TVTIRFYLSK LKQNSMKLSE LDDDDVHLQE MPLEMNFSSR TSSLDAQRTI
EDNVEKRINT VLGPPAKKRL VVFIDDINMP KMDLYGTQQP IAFLKLLIEH QSWYDRKDLL
FKTVRDTQFV AAMAPAGGGR NALDPRFVSL FTVFNIIFPE DESIHAIYTQ ILQDVYKDLH
LSNSEQLAQT ITRATLSLYQ NVVSALPATP AKFHYIFNLR DLSRVYEGLC RATPEKFGVV
RNIVRVWRNE VTRVFADRMS DQSDKRYMSS LIEEEIKRCF PEEAEHAMQD PLLFVDFADF
VPDSDAERLH IYEDLGPDYA TARRLVDSII EEINTPVVKI DLVMFDMALE HLLRITRVLS
LPQGNCLLIG VGGSGKQSLT RLAAAICQLG VFEIALTRSY NEDSFREDLK QLYLSVGVQR
KKMVFLFMDS HVKEEGFLEL INNMLASGMV PALFTEEEKE PLYRSVTNEL IRDGLDLSKD
NKWSTFVGHC RDNLHIVLSM SPSGDTLRTR CRNFPSLINF TTIDWFEKWP AQAFHAVGRK
LLLPESLPEG LLDSIVEHMV YVHTTADELS MRYQNELKRH NYVTPKNFMG FLANYSKLLF
TKRESMDDIV SKFTIGLERL QKAQDDVEVL QKELAIKEVT LLEKQSVNER MTREITDQKS
KNEARKAEAL AMEEELNVRN EEIETETAEA QIVLDQAMPA LEEAMEAVKH INPKSITELR
SFAKPPVNVV AVVRMVCVVK GVASTWEAGK IMMGQSDFIR SLVDVDALTT TLNQSKINEV
NKILKEFPVN SNDLKKVSLA ASGLMIWVEA MKQYWNVAKE VFPKQERVRQ LQRAKENAER
QLNLCRQEID TLTENLRKLE HRLEAGMCEA RRLQQEKVIM ERRLSAARKL IDGFGSERTR
WTEEKARLGS ARHCLVGDCL AGAAFLSYLG AFTFPYRQEA LERLWLGDLR QRGIPLTTPF
DVNHLLTDEV AISQWASDGL PSDELSIQNG ILTTLSTDYT GKGKRSGRIR FPLCIDPQMQ
AVKWIKRQHK NNPRFETASF SDSDFLKRLE FAIQYGNPFL FEGIDEFIDP IIDSVLDPKF
TYESGQRLIR IGDKDIPWDS NFKLYLCTKL SNPNYPAEVF GKTMVINYGV TEGGLESQLL
NYVVASERSD LQRQSEELVQ TMAESRSQLK ELEDTLIREL TLATGNILDN DDLIATLENT
KSSALEVGQK LEQAKETAQT TELSRQQYRP AARRGAVLYF VISQLSSINP MYEYSLSAFL
HDVFGYSITK SDPAFEIKDR LQNIIKALTY NLYNYVCMGI FEKDKLMLSF QIAIRLLSQE
GRLSMSELEF FLRGCILPSK DFPPNPTDWL TERQWHDLCK LSTICETFAS LPDDVRDNIE
EWKEWVLIDR PEDAENPLPC GYSERVTEFQ MMCLLRCFRS DRVYNAVSNF ISNCDLLGPA
FVVPPILRYK DVLDKSSCLS PIVCVVSPGA NPTGEILELA AKEVGLDKLR AVSLGQGQGE
EAMKLVEVGA VRGHWVILQN CHLLTDWMKS LEAITEKMDQ QQVHEQFRLW LTTEPTPDFP
MGILQRSLKV VNEPPNGLKM NMKNTLSKVS EEHLDVCPHW AFRPLVFTLA FFHAVVQERR
KYGKIGWNVA YDFNETDFTV SMRLLDTYLT KAHLNSDPIP WETLRYLVGE VIYGGRVTDS
MDRRIVQTYL EEYFGDFLFD TFNPFHFFAN DTVDYALPRG STNPHGKLTL AAMLAHLEGF
TNTNTPDVFG LHLNAETGYL RGAAEKMWLS LMELMPRTGT TAFRADARDA TLRRLTDDIL
AQLPPPFDHT QLRKRSHERA RAAGADGLPP TQVVLLQEVX XXXXXXXXXX XXXXXXXXXX
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CVCVEWGGGG GETIFSRFAL LPPFY
//
