ID   W6KHS7_9TRYP            Unreviewed;       406 AA.
AC   W6KHS7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=GSEM1_T00004671001 {ECO:0000313|EMBL:CCW61119.1};
OS   Phytomonas sp. EM1.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Phytomonas.
OX   NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW61119.1, ECO:0000313|Proteomes:UP000027080};
RN   [1] {ECO:0000313|EMBL:CCW61119.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW61119.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCW61119.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW61119.1};
RX   PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA   Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA   Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA   Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA   Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA   Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA   Wincker P., Dollet M.;
RT   "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT   Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL   PLoS Genet. 10:e1004007-e1004007(2014).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; HF955063; CCW61119.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6KHS7; -.
DR   EnsemblProtists; CCW61119; CCW61119; GSEM1_T00004671001.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000027080; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT   DOMAIN          30..274
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   406 AA;  45678 MW;  8E480D28A955E98D CRC64;
     MSETQLNPAL SYAQRIAAAA CYPPVPKRCV VTGGTGFVGT RLVEMLVERG AEEVISFDIV
     PKEKGIGIWN HPLIKYVVAD ITCFEDVSST IKGADCVWHL AAAVGPFHPP DLYRKVNYIG
     TLNVIRACKE HGVKKLVFSS SPSTRFKGSL FHRPNIDGLT EEEMPHLPLN RYMQMYAETK
     AEGEMAVTAA CDDDFWAVSV APHQVYGPRD NLFLPNVLEA AGTGKLRIFS KGDNRICFTH
     VDNYCHGLII AERKLFRGSP ILGKFYIVTD GSTHPEPGAY CIFWKEIDKA IVKMNFCSIQ
     KKIHYPFWFL YIAALIAEVL GRLMHTTFKL NLFNVFVLTM NRWFRIDAAE EDLGYRPIIS
     FSEGWEDTIA WFKDNWLPKF LKEGSASIVG LSQASQHKID IQAKSK
//