ID   W6KIU4_9TRYP            Unreviewed;       584 AA.
AC   W6KIU4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
GN   ORFNames=GSEM1_T00004466001 {ECO:0000313|EMBL:CCW60963.1};
OS   Phytomonas sp. EM1.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Phytomonas.
OX   NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW60963.1, ECO:0000313|Proteomes:UP000027080};
RN   [1] {ECO:0000313|EMBL:CCW60963.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW60963.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCW60963.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EM1 {ECO:0000313|EMBL:CCW60963.1};
RX   PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA   Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA   Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA   Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA   Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA   Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA   Wincker P., Dollet M.;
RT   "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT   Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL   PLoS Genet. 10:e1004007-e1004007(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR   EMBL; HF955063; CCW60963.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6KIU4; -.
DR   EnsemblProtists; CCW60963; CCW60963; GSEM1_T00004466001.
DR   OrthoDB; 169924at2759; -.
DR   Proteomes; UP000027080; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR   PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          85..119
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  64443 MW;  87F8DAB1AAFD21FE CRC64;
     MAHIKDHKTN ETRCPPKEAL ETSDNVHGGE QTLKPAKGTS QGMKKNSSGE AKPADSENSQ
     IQEKEAKKLA EMRFKGQESE NARASIKIQR EIKKKKNALN KVQKKLKSLK SDEDEFAQTK
     GEEAQLLKEI ISMEGDLQCE TQKVSSAPLS TPSVKVSPLE NASKPTSTAH PTDKVVKGEG
     AEVKEQQDVE EARRKLQELV KQAMQSNNHI QRKHFMPRRS VVHPRVAEVA LMIEEMRIVG
     GNARTMATIY AFSEMLKCTA VLAGSSLKDV NTTIFEKLVE ENFAFLRRKR EASVGMHYVK
     KALLQRMVAA RDKGSQLGDP REVALQLLGS LEAELCMSIK TIVEDRSLPY VSNQDTILVF
     GRSSVVEFIL LSRVEDPQRR PKRVIVVDSG PLFEGRALAH KLSDAGIQVT YGLITASCML
     IPKCTKVFIG ASSVLQSGDV FSRCGTALVA ACAKSFRKPV LCFVESYKFA AEVWIGNLAQ
     NTKLVDIREQ PSFNSSGAHS PLIHNLSPSR VFANDPQHRI PDDYNSLKDI NAMHYGSSSA
     SGYLYDLTPA TYVDMIVCEM GCLHTSAIIA VIKDREGLEA APLM
//