ID W6L1W3_9TRYP Unreviewed; 4142 AA.
AC W6L1W3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCW68460.1};
GN ORFNames=GSHART1_T00005337001 {ECO:0000313|EMBL:CCW68460.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW68460.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW68460.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW68460.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW68460.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW68460.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
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DR EMBL; HF955202; CCW68460.1; -; Genomic_DNA.
DR EnsemblProtists; CCW68460; CCW68460; GSHART1_T00005337001.
DR OrthoDB; 159333at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd11709; SPRY; 1.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00622; SPRY; 2.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053358};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1917..2119
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3432..3622
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3819..4142
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 4110
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4142 AA; 465788 MW; 1AC1E03F671BFE04 CRC64;
MYEENISCLS SIPPQHSERA VSINLLPTEA YANPNNEGLP LHSTTYNAKP SQPVCFQNGS
VYIQDSHNAS SNGNGAVKIR SFDMSDMTLS QVYTMGYRSY LHKKQADESM YHFPVAPPDF
DGSAPTNLEA VAQYVDKLAV AYKSVHRIPT PFNMYEHIIL EAADNLSNTS MNQIQQSNNT
NSPPIRSLIN KHSQLDVPPK NEVPSTALVD QQQATEAFVV SLSLVNLKRM GCKEMQLLFE
RFRTSPRVAS TVDSDVITSV LIDFHAMLMQ EETSCDKQSH LISLVGMLVS SRSIIKEVLQ
YLNILEEFHA AYSNILPMYV SSASSIIDVF TLHSKSLCPI LSPIDCFQEE DQRLKVNLSE
GTTMQCFCVS ADGYLLAAAT LRGLEVYEVA SGLPIANRES GAPEGSKSYW TITFSEDLSK
LICSDVAGLN HTIYTSDLNV VEEIRTSEVS IPLDYKNGVM EMLTSPLLPS GSNRSLYFFE
PGSCLAEIEL ITGDEKESFT MCVHVHQDFE GTLAHFFTES GDIIVSVTRC CFRFTQNGVS
CYGIASSSSP WLYVHARWHK GTWSLDVNTA IVDLAGARND QQKSLRIHKV LCLDGLGHVG
SFALWLDADD AGVVAMYRRE RRLESCNALV NFPLDEGIGM WVKEAVSCMA FTISETQCAW
DENILVPCLS SAEEDPLERQ LTVCMDPKLL LESRILTSRF KVYMILPSHV KGGDDVVVLV
DRAAKKITRI SHCPRSCSEN IYALLSDESK LFVYQQRFST FSSIRLHSMQ CKLNELDKSG
LLDVDLPANS VRWLRHEWYK KIYLEVFELH RIPLANTPLS FTNLFALADS FLNVKANTDK
LYVVVILSLT LVHFQMLISA DETHISKVAT LLKSCCKKII DMFPENIISE TAHELLNAAT
SKSLTLNDKV QALLDPDMER SMATLKVYVT KESLFTLIHH IVTNSPAILT DVARRLIVMS
RAETTSLNRA AAQPITQLMT NFVLVCVKEL MSYDKFSEIS QLVELFVEFV QQELPKAGSG
APMQNTILYT GCIPLFIAVA HFCPWVLTNK IEQSFLSILH ELKGKVGSEE TVSFTTREAC
YVFPPHRERD TMWRFVIDFS HANSVAVQKE SDMPPLSIIR SDSTTFQRSK IEMSRERTFL
KLEGGRLAFF GYGENNFTIN SQFDFSVLTS WESLLSDCVH NLLVSLARHL IHKPKANDTN
VPPIMRQGLN ADTLRRHDIN FDSREIHHFT FALDILNNVG DGRAFVDQVY QSMRGSIIPS
MRPAIQALLA ILIHAGVNAQ QAEDELKLRW FSGEWGVKLQ GPSRDATRTF LNDFANWFIK
SICYQMEGMT VAFRRGSCDR RLENSLNNSR SISERHRSTS SRRSIFKHSQ QSETLDQLKT
LLAREMTPFA LEEILVERTQ AAIKMVHCIS LLRSLLRLED TEQASEVSML AILDVLSIFV
NVDSGSHYIE SLNGAGFDLQ MQVRTELHSV LMQCQELLIG KCQNNIAPQA VLTERATNGL
ATMQLLSILC HPFDALDAEI FNANFGNENA LLKYLENHIS ILTSSLMLMN PWDLHKDTGT
DLSAPEEREL RFEPMGEVDL YSISYIYPND FTIVIPQLLT SRSEEGVLIE NNNINSVELS
ADEGWPLTWK DGMPRVFYYE VKIKSLVCKL DVGLTVSRLN FGAIRLDSLY FYSSSGDTHS
ISFPMFSEDD TVGCGFISTN RRIFFTLNGV LLGLMDTVPE KQDILFPTLR FSERSGAKVL
VNFGTSTFVY DYQQLHPALN LRRGPTWYRV ASTAAITLHH IAACACLMQE VRKSSASVFL
THCFEVVCQK VNKVTTFLMN TGIGSTNHTN SYIRIKQSVI FAVAEYSIML LIATIRHIVN
TGALYNPLPE VVGEMIFDAV SVLMLLPLRL TQVAIISILP EIIPHVRHQP DGTALANLVR
TLFRHANDPV AEAVYTIPFT PTWCECDPRS MSIVNVQSAC MNPESQRSIV LGNVLPRTGV
VSFSVKISRR NMSKGHSLKG GYFIGVSVAR LSPLSPTSNS QSWKTVKPPI VWAMHDTSPQ
LPHATNPIVK ANNFQRTFGN DDMIRVVVDC DNRTVDFYRD DELLRTLFSN LPADIDLVPF
VQVYNDDASV TIYPGEMTSP ISTSTLLSAA SVDVLRAMLM LEPFQFLVAK GICNELDMHA
YPKVTLALFN SLPDRRMLQL RSRTGEEFFI TVSRVGDVRC KFSVGNEANY EHLYNLHTPA
NPKITCSLDT QILSGSSGGL GLCIERLVAA VRRIVLPFIT TQALSALEHE QRSKIIDEEK
ERWDFLFHGL RIGSFINIQR SSQVKKIIPT PHIPIDYTFS AAMSHPSFCM PKTYCGRLAT
IPSGSENVTT PFITIADPAV PSQGTFSIRC QLIRGHNGQI LGGGYYFGLC TSTFNWKRKD
LNSGVPEVWA IHDMDDSPWR LRHFSSTCTL PMAADPRCVI VSGDIIRLEI NRDEGIMRAF
RKPFDSEEIS FGIIFDNLPT GNLHPFVHLF NVDSVAVLLP SKNTDSALRF TVQQPLFSTY
SFNERRYCDG CAAQHLESRL SKQWYKCVDC ADYALCKSCF DLCVHSHHTF TDMGTYSLVH
TKHTPTKITK GMQVVIPATS CMYLRSNGCR MDEGSINCVA ESIEDNSFAI WGLVFKDRTH
FTATIETLDN RPLRADRLVF IGVGLTNEIM QLSRGKLLNS CFSPSSSVLT YCNYYSMRRE
INSENRHSHG FDNGSTITVE LDVVKKTATF IRDWIVIDTC PIEFLTSVSN HHLALCFFVV
FEKKGVKVVI RPESGMTMIA RVEEANGSIV KVSAGDSGIR YVTPENCRLP LQQCNMAPEI
GRLGYIYIDK RMVQCLLVGM ENGEAKLCLA KDDSVHKVPL CHFLIDEYKA IANEHLIQKE
SDENGATLLD GFVVSRLLLI LSCLCENEPL SPLVIQHGTE LINLIKGLAS VQINNYTPLN
FLNEVRTLIA ETANTVRWIN PSQRLGYFVP TLGIDDRKRR FKPGMLVECI TTGSSKDFYK
VVVRKGEMLT LVNLETSESV EISYKNCIPV KQSNGKPWYS VSNGLPCSFR ERTIRLTQSI
SEFQSVSIKG IWQGELVFPK LKAILFDLTL QNSGTGTAFL HIHGQKIGYQ AIYGHIEYQR
IVYLCLTRND PSGTNKAYQL INTENIVSYV RRMHQVMSAL ALSDVTDCYM AELSIDAEGL
CMSGVCCNSN SKTGSLVCYC PDRPQLISSY TDMAHIEPLP DCVDTITMAK PLRDLSETMH
RLVILLARHL YLLICSKKNI ISKELVENVF LFNTHPLTDR LVTSFVGIPQ LFFMVCDASQ
RITNPDVRPW DAATLSTLIT KTLLLRPESL AKAPESLIWD SLHAVVVAMH RCGSQFRHNI
MRKVTAFVRS HRDNEQKIYW QLFSALVTYF DRNVLSSTTR SNDMHKDIAA GVDLILNFKA
QEPWHLRNIP TQPLHCLVDI WQSLVEERPL PYVVDETNDH HGDNELHVDV VCAFGDYSDE
ELKVGKVMSS ISAVLSGQYY YEVILPDRLI SPFAVGWGTQ AHCEVPSQHV GSDRTSFSFN
GSEVSTKDTK EDYKITQEIT PGCVLGCLLR MEEQVVAWSI NGTIGPFIPI PIALGDKGLY
AFVSTGICSG LRVRLRASEF EFVPDGYTDL AGHYTRVLIA NYDESVRSSL PVQNLSFYSQ
IASYLSDLTE YKKEDKKSLE ASMSATFILR LAATNLFLPK YSALIGLSEG ELKGYERVIE
TVESCMATAS RFVDLDSDVI RGTLSVAFLY LKPLVRRSFR QKLLINIPGV EKATSPSSIS
IRITELFSTL PRTPDVALHY TVLSQLYRQI GGFTEEQWSQ SPLFKVNLYI SGSGHAPIDM
GGPYRQVWTF LAEELVRHPD KCYPHSDFHR NPLFCFVDNS QRVSLVPDSL ANSSLELALF
NFFGKIMGHV ARAHLPLNID FSPFLWKFLV DDVLTVKDYY KYVDSVVENS MEDDNFLLSG
VAEEIIPNFA ENIMWLDEED LKGEKLINHR RRIAENCLVH SMDEQLNAIR SGLWTTLPRR
VVRCLSWCDL ERLVCGESNP STKELKRYIH TQLNPTCEKY FWEILEEFTA EEKAALLCFA
SGQRRLPLIR QIIIQENNES LEHLPRAQSC SSLITIPPYT SLEMFREKLL LALQHQDEME
LA
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