ID W6L9D6_9TRYP Unreviewed; 1026 AA.
AC W6L9D6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Transketolase-like pyrimidine-binding domain-containing protein {ECO:0000259|SMART:SM00861};
GN ORFNames=GSHART1_T00001494001 {ECO:0000313|EMBL:CCW71100.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW71100.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW71100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW71100.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW71100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW71100.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; HF955209; CCW71100.1; -; Genomic_DNA.
DR AlphaFoldDB; W6L9D6; -.
DR EnsemblProtists; CCW71100; CCW71100; GSHART1_T00001494001.
DR OrthoDB; 3597773at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053358};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 631..847
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
FT REGION 894..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 115176 MW; D224EE777F887E40 CRC64;
MRRLFHPRRL TRAVFLRCYT DAQTIREPNP YEQILASDNQ EYMENLLTQY EKDRSSVDAS
WFPVLEAIRT GNLELPVVTA FSRPIDVKSL SVKQRLDNMR LAWMIKEYES KGHHVARVDP
FNGAFVSSRS LNDLHLDPSA FGFTEADLEK VFLVTFGSNH KATFVSGGTG MTLSQIVQEL
QKMYCGTIGF DFAFSGPDAL CQWFRNEVYN TLKPLPVEEK REILNDVVKA TKLEKFLYTK
YPLHKRFGLE GSEALVLALK AAILEASNHG VEHCMFGMPW RGRLNVLANV CGKPLKDIFY
EFRDDIAPDG ETSDDLFLNL GFNNAINLSN GKQVGIEVLP TSAHAEAATA MVLGKAHARQ
IYTNDIARIH TMPILIHNDG SMSGEGVCYE LMGMCNLTNY KVGGTFHIVI NNQISFTTDP
RDSRGNFYCS ELGKMNRTPT MRVNGDDVEA CVRAARIAVR FRQQYQRDVI LELVCYRSYG
HDVGDIPDLT HPNMYRMIQE HPRLIEIYSK SLIDEGVITA PDFKAKESDC EEAMQNAFER
ALTSQVFPRT IPLFHPESEN IAEDLPSEVV KAVETLLNAP PPAVITGENY DILKSVGLHI
ATIPKAMKKP HPVVERTFAN RKKGIENGNA VEWCQAELMA LGTLSLKGTH VRFTGEDVER
GTFTQRHACI TDMETNEKYT PVATISPNQA LFVMGNSSLS ELGVCGFELG YNMANPRNMV
IWEAQFGDFA NGAQVVIDDF LSAGERRWGW QASLVLSLPH GYSGAGPEHS SARIERFLQL
SDALDVVPTT FRKLPNDQML EARIRNRNWQ VCYPSTPASY FHLLRRQGLR DFAKPLVIFF
SKARLRAPNL SRLEEFAGET SFRAVLDTGA PRGRGRGRAD GEAAPAALLH RPNRKYRRRG
SRRRAGQDAE PTRRFDPHHA RAARALPLGA GRGCDREVHR AEPRGGVGVA AGGAEEYGHV
VFYAAADEFP HAAPRRPPAA DSVHRPQELR LPVHRLRLRP RRGGAPDRSG MFRLETNLER
QGFYRI
//