ID   W6L9L2_9TRYP            Unreviewed;       697 AA.
AC   W6L9L2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=KOW domain-containing protein {ECO:0000259|SMART:SM00739};
GN   ORFNames=GSHART1_T00008059001 {ECO:0000313|EMBL:CCW70459.1};
OS   Phytomonas sp. Hart1.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Phytomonas.
OX   NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW70459.1, ECO:0000313|Proteomes:UP000053358};
RN   [1] {ECO:0000313|EMBL:CCW70459.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hart1 {ECO:0000313|EMBL:CCW70459.1};
RA   Genoscope - CEA;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCW70459.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hart1 {ECO:0000313|EMBL:CCW70459.1};
RX   PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA   Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA   Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA   Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA   Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA   Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA   Wincker P., Dollet M.;
RT   "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT   Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL   PLoS Genet. 10:e1004007-e1004007(2014).
CC   -!- SIMILARITY: Belongs to the SPT5 family.
CC       {ECO:0000256|ARBA:ARBA00006956}.
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DR   EMBL; HF955206; CCW70459.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6L9L2; -.
DR   EnsemblProtists; CCW70459; CCW70459; GSHART1_T00008059001.
DR   OrthoDB; 24955at2759; -.
DR   Proteomes; UP000053358; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0006354; P:DNA-templated transcription elongation; IEA:InterPro.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd06083; KOW_Spt5_3; 1.
DR   CDD; cd09888; NGN_Euk; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR041976; KOW_Spt5_3.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR039385; NGN_Euk.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR039659; SPT5.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR   PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   SMART; SM00739; KOW; 2.
DR   SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053358}.
FT   DOMAIN          409..436
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   DOMAIN          465..492
FT                   /note="KOW"
FT                   /evidence="ECO:0000259|SMART:SM00739"
FT   REGION          17..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  78740 MW;  E61696BDB9AA8832 CRC64;
     MTETNLNLEE LEGLLVNGST LPPETSIDIS VPPVESAQNA FSDPEEAAIK PKSKKSKKRR
     YKERSSSPIT EDREWKKSKY VLDAAESTDG DEDEFVEESN EVEEGLDEGP HYEAPKRFIF
     HEGDETKSAD ELGREFEERY QRLKKQRSIE DLQGIIPREK LSSLRYASYL LPKDSDPKVF
     AVKCRSCMAR TLVTRIVNKC YAYRVGKNYE KKKVDLGIIS VFCIDHVKEY IYIEAYRKIF
     VESAINGLEG LFRYNITVVN PTQLLQMVER RSPNEKIRVG SFVRLRTRFY RMDLAQVTSV
     HQDGVHIDCK VVPREDFDGK PFSKVSAPLP PQFFVASRAV GVEDRGDHYR WGDLRFDKEG
     YLIKTFSSRM VISEPQMEKP TAEELARFYN NNRERVREAL SHTGVSLAVH QIGDSVRVAS
     GQLRNTIGTI VDIFTNDNTA LLSCAAPNLK DLIKLRVELT SLVKHFAEGS HVVVRSGDYA
     GESGTVVKSW NDVVLLFLDR PSSVTEIKVS ANDCHQSKLT QMLRHSFGAW KLFDLVSIVE
     ANTVACIVGL TRNDVVVITE RNEVQTLTYA QLKSINVRGV RQTTDFMQNV LVQGSEVTIQ
     RSAFTPFNLG GETGRIQQVY NQTVFVCCRS IRENAGVVAL SASCVLLIGG RTTTKQVAPP
     KQLPMPNRRM HNAKKVDISI PSNTISADWQ INSEWCE
//