ID W6LAD4_9TRYP Unreviewed; 4211 AA.
AC W6LAD4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSHART1_T00007685001 {ECO:0000313|EMBL:CCW70167.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW70167.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW70167.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW70167.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW70167.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW70167.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
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DR EMBL; HF955206; CCW70167.1; -; Genomic_DNA.
DR EnsemblProtists; CCW70167; CCW70167; GSHART1_T00007685001.
DR OrthoDB; 168388at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053358}.
FT DOMAIN 811..1208
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1342..1668
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1961..2034
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2259..2349
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2401..2656
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2671..3003
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3032..3253
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3564..3677
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3712..3853
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3907..4207
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1909..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3450..3507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3873..3911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2705..2737
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2887..2935
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3194..3228
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1915..1937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3456..3471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3478..3507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3881..3910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4211 AA; 482123 MW; 9175599ED882734B CRC64;
MERMYIPSDQ AFREKLQSST CQNIEPVSLI ERHVNNELER VRNPRKLYKF QRPREFSFKG
RAVTADASIK RIRYNGKINN YAQSEETDYN DHDVKLLRMI QRACKKPRID EKPDKTVAPN
DDVLKSKLLT DKDVVAFFSI HGDKSPLKYV ILNPTPRSLE FRPYDLVVSH KGEEKAEHYI
MSATGVVHVR PNCPSEVISL GDWVEEKSLF NVLRRIPFFK NFLLYKAFFR LYKKLREKKF
AAKRKMLSND FLLIKSTFLA TQQDLCKTSN ELSNVALIAY EPQGKHDFFI EDFRMQQLRQ
RQKASGEINS TLERVEEKVT NLINCLQSRA DVPDMTTRAA IEQYLMSSEL SSIELKRVKL
LKSMIERKGE QIRKLLELKR SLVEYSQIDV FVRLVDLMMS ENLFKNALST SQVFFNILRN
QSGESIRKVG FQVLLHPKPT KMDFDPSASV VKNLFIEIVN GYSDLVSSVT RLSEQRYYKA
FFKKNPRLWN IGLKIKKDAR FNFLQQSMIQ IIKNDYELAY VRMGTYSAVL PDIHFLQNEW
TQIEKEQLEE NKEAHHSSTS LAKLYRRLQK AQDSLRVLMS TFVGNTLWIN ATKLKSEIEP
RVQILKEEVD ATLRSVTCDV IQKLHTNFKH KIQLLNERPQ TLSDFAEYVD EYKKVKAEMP
AIEDSISQAE ALCEIMDRHQ VEFAEDEDKQ LKERTLGNTS MVASLHAVFD DVCLKAEEFI
EEHLPFHVET LVSQVANLEE ECSGIRHILS GKEFVTLVDI IETVIEYLDN IMSNLDDISK
TRACLTRYAN LFDHSSLNWT VLDETISLAM SRKETWTLLD EFSKKVEYWF DCPLDELNTE
EMEEEVISML KRSDIANRTI KAKDYEDEII PHLLHKLHAI RQNITTIHDC GNKHMSSENW
NVVLKEVVGP MCTYHRELNL NFLQEHGIFN NKEILSEQSG LATAQWKINN DLDGIREIWD
AILINLKPYK NREGVFILSD LDDIIQQLDD HQIELQTIMA SRFAASIRGK VETWIDNLRL
VSNVLDEWIT LQKNWMYLEF IFSSDDIKEQ LPEESKSFDK VDRFYCTLTT KASVIRNVYQ
ICTEDGLLDD IKRSNEYIDH IQKRLEDYLE TKRIAFPRFY FLSNDELLSI LSDTRNPKSV
QPHLPKCFDS IALLIFEDEE YNSILGMISG EGENVMFPRP IHPVGGVEQW LNEVEGIMKI
SLHQHTQKTI EAYSRSPREE WFFNHPAQCV QAVDMIVWTG EVEEAITADS LDTYHANYQN
QILNMVQIVK KPLNKLNRAL LCTLIVLDVH NRDIVQTLHQ RHVVEVGDFN WHQQLRYYWE
KDAGMPNGMN IGIAHCNAHL WYGYEYLGNQ PRLVITPLTD RAFLTCTNAL SMNLGAAPQG
PAGTGKTESV KDLGKALARQ VVVFNCSDGI NYKTMSRMFA GLAQAGAWAC FDEFNRIELE
VLSVIAQQML EITTALNQKL ERMNFEGHPI QLNKNFGVFI TMNPDYAGRN TLPDNLKALF
RPICMMIPDY ALIAEIMFYS EGFSDARTLA KKMVQLYKLS SEQLSKQDHY DFGMRAVKSI
LVMAGALKRN DANEKEDMLL IRAIRDANVP KFLRDDNILF MALVRDLFPS VKIEECHNEL
LLDYIQRIME KEGLQIVDGM ITKTIQLYNT LEVRHGLMLV GQSLSGKSAV IRTLQHALIN
LKMDGHDEDG KHPLYNRVQV HFLNPKSITM GELYGHVNEI TREWTDGVLS GVARYITRTA
LDKPDRHWVI FDGPVDALWI ENMNTVLDDN KLLCLFNGER IKLPNTATFM FEVQDLKVAS
PATVSRCGMV YMEPYYLDGD RGWIPIAKSL IRRKAEANEF IQAERLMTLL EQFVPDTLDF
LRKNCNEWIP SIDAQLVINC IELLYAFVKA RDQSNLWPAG ITRPIEEAAN EAENNEDPNE
QSYLYSSSSN MSNPRQRKSV CPPPDIFRCP PITHATVAAP NEERLFDMYF IMAFIWSFGG
NIRDDARGTF SQFSKEKVSQ LMPGLLPSDP DKDENLSLYN LVVHLPSKRF TTWDYLVPDF
NYQPDVPYFD HVVPTADSVA LKTILHVLMN SSRSVLINGV TGTGKSLTAL NFLQDTLRTD
EPDTVWEYFG TVLSSQTRSK DLEMRLLSKL TKLRSNVLGP TMGKTAVFFV DDLNMPALEK
FGASPPLELL RQVLTQGGFF DTHKSPASFK HVRDLVFLAA CGVPGGGRNS MTTRLTSRFH
LLCQPAMSTS TTTRIFGSIL YGFLYQWKSS EVLGLSMPLV EATRQCYERI TQEKLPTTTR
SHYTFNLRDF GRVIQGMMQA SPKSAPGKEE LCRLFVHEVS RTFHDRLADE GDRQWWWRTL
KEVLEKTLDF PWSEDFPNLL FGDYMQRNRV HYEEIRDHDA IPDMLSEYLN SYNMTYNKEV
DLVFFQDAIK HISRICRVLR QPRGNVLLAG MGGTGRHSLC CLAASICDLP VHELVLTRSF
GLAEFHETLK KILMECGGRD KSVVFFMSDA QVVREEMLED INNLLNTGEV PDLMLAEDVD
AVVELVRPLA IAAGRKETRN AIFAHFVSTC RDQMRIVLAM SPVGDKFRSR LRLFPSLVNC
CFIDWFDQWP SDALDAVATR VLDPVPIDEP VKRSLVQLCV KIHLDVQKSS VDFFDELQRR
NYTTPASYLE LLSCYCEFLQ ERERSVREQI ERYQGGLNTL RETERIVDEM KGQLVEMQPR
LIEAAHDTQT LMEKIEKEKE EAEVVRKECA KDEHEASEIQ AEADGIRAEC QTELNKALPI
LKSAEDALAE LRPDDIREVR SFQKPAARVV LVLEAVLTLL GEKDVSWERS KLVMSRMDFI
KDLQNYQRDE LTEKMIRSIQ KYVNNPDFQP DEVAKSSKAC RSLSLWVLAI NNYYEVVKVV
APKRKRLAEA EAKVAVANQS LQHARGRLNA IEEALSQLQS DMKENIRKKE KLGEDIELIT
VRLGRAEQLM SGLSSEQLRW SDSIVALDEE RSGHVGNIAL AASFVAYLGP FTHAYRARML
KMWFDSCRSL HVPVGKSEVF DVCKIVDPVR IRAWGQQGLP PDSFSVENGV VVSKSRRWCL
CIDPQGQAAS WIRELEKKND LRVVKLTDSN YLRILEAAIQ RGLPVLIENV EESLDATLDP
ILLRQTYHSQ GRLLIKIGDS EISYDPNFRL YITTKLPNPH YLPELQIKVT ILNFTVTQEG
LENQLLADVV RFEYAELEQR ADATIVEIAE VKTKLKEVED NILNLLSSST GNILDNESLV
AALQDAKRTS ESVSASLVVS EQTQREIQSA RDRYRPVATR GSIIYSVLSE LAGLDRMYQN
SLVFFKQLFT KTLNQTPRRE NVEERVGLLL PAITLETYGT ICRGLFEKDK LIFAFLLYSH
IARHAGEMSE EEWLFALKGS EGQSYLSDMN YRTPDWLPAL QWNEVIALST RIKKFAGLLD
EIRKHPDEWK AWFADDKAYE RFPAFMNELD QEEDEPLQEA TPHKTEEEDE APNEDKPHEE
EENDALKESN PHEEEDKISE KANRTEFSEP QKRFSTWEKL LLLKAFREDL FNHGLTLLVE
EKLGKEFLES SGFDLEGCFR DSSPSAPIIF ILIPGTDPTS LFTEFAERKG FRSRYHMLSL
GQGQGEKAEK MIRDGWLDGV WVYLQNCHLY ASWIPTLERL MDGMLESGVH PNFRLWLTTM
PTPAFPVLLL QSGVKVVKEP PKGLRANIRD TFTQILTPDG WENGGMRNPT AWRRLVFSLA
YFHAVIQERR RFGPLGWNIP YEWNQSDLAA SLHTLSVYIP HEGPPLPWEA LYFMIGVINY
GGRVTDFLDT RCLGTMITSF MNPDAVRPAR YDLTQDGIYH IPAETASFRA IQTYLAELPN
FESPEIFGLH GNAETTLNRR AVRAGLAAVL AVQPRRKAPA PSGEGRAEKE KDGAANRPNA
EDEAPTDKDG EGRMLAMVMA LKGRLPPPID PAAAHPSSYQ KAADGTISSL GTVLRQEVDI
LNGLLAMLAG SLTELFRGIK GEVGMSCELD EMLDAILIGA VPRMWLERGY LSRKPLASWF
VDTLDRVAFF RAWNDHGLPK SFWISGFYFP QGLLTAFLQT YSRPRKIPID DVVFQTKMTI
DAGPDDIEED SGDGFFIHGL FLEGARYDIG MGCLAESRKG ELFTSLPVIH LIPVRQSLLS
EDDENKKKKT MYSCPVYKTA ARVGMLSTTG LSTNYVISLD IRAGNKNDEN FRATPEHWIK
RGVAILCMLD D
//
