ID W6LDN8_9TRYP Unreviewed; 507 AA.
AC W6LDN8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN ORFNames=GSHART1_T00001840001 {ECO:0000313|EMBL:CCW71367.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW71367.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW71367.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW71367.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW71367.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW71367.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; HF955210; CCW71367.1; -; Genomic_DNA.
DR AlphaFoldDB; W6LDN8; -.
DR EnsemblProtists; CCW71367; CCW71367; GSHART1_T00001840001.
DR OrthoDB; 169494at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053358}.
FT REGION 146..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 54875 MW; 3D97A1C64DE0757D CRC64;
MLSLQDEPEE IIQDVNDLVE TFITNIKCRR LSEYSSDGES LSTIAAVQMT DLMATIVRIF
QQYEERPDGF GMQMLKAGYP VLEVSTLLVR RLLVLIARAG DALLRAQFAT LLLMNVTRRV
LSLLREAAAN NRATVQELEL EAKRLLDGLS SDDEGEEKGK PREEAPERGR PLQHVASSPN
SLESSPGTQA TRRRMSVRFA GSPPALEGGA PERFPRNPSR GLLHGVGGIG ASEIPGQQFL
RRAPSQRAGS SDPAEEGTFP VKVFPFFEDA LNGIDELKSE IDGMVEELCR RAPRQLHRSD
TVLTMGASRT THRYLLQAAN AGCDFKLILL EGAPGPRGPC EALAASLSRC GVGVQVLPDS
SAFAVMSTCT KVLVGAESVL ANGGMLAPVG THMLCVAAKH FAVPVLVATT TLKMSPYYPN
NQLCTRLVRI ARTGAQEMPW STYGSPEGVL PSPFGQSCAD GGGVFGVYAP ITEYVPPELI
ALYPTNETEF TPSQVHRFVR ANYSDAD
//
