ID W6MHR0_9ASCO Unreviewed; 365 AA.
AC W6MHR0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000256|HAMAP-Rule:MF_03037};
GN Name=CIA1 {ECO:0000256|HAMAP-Rule:MF_03037};
GN ORFNames=KUCA_T00001506001 {ECO:0000313|EMBL:CDK25536.1};
OS Kuraishia capsulata CBS 1993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Kuraishia.
OX NCBI_TaxID=1382522 {ECO:0000313|EMBL:CDK25536.1};
RN [1] {ECO:0000313|EMBL:CDK25536.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK25536.1};
RA Genoscope - CEA;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDK25536.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK25536.1};
RA Morales L., Noel B., Porcel B., Marcet-Houben M., Hullo M-F., Sacerdot C.,
RA Tekaia F., Leh-Louis V., Despons L., Khanna V., Aury J-M., Barbe V.,
RA Couloux A., Labadie K., Pelletier E., Souciet J-L., Boekhout T.,
RA Gabaldon T., Wincker P., Dujon B.;
RT "Complete DNA sequence of /Kuraishia capsulata/ illustrates novel genomic
RT features among budding yeasts (/Saccharomycotina/).";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000256|HAMAP-Rule:MF_03037}.
CC -!- SUBUNIT: Interacts with NAR1. {ECO:0000256|HAMAP-Rule:MF_03037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03037}.
CC Nucleus {ECO:0000256|HAMAP-Rule:MF_03037}. Note=Preferentially
CC localized to the nucleus. {ECO:0000256|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; HG793126; CDK25536.1; -; Genomic_DNA.
DR AlphaFoldDB; W6MHR0; -.
DR STRING; 1382522.W6MHR0; -.
DR HOGENOM; CLU_000288_57_8_1; -.
DR OrthoDB; 5486866at2759; -.
DR GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19920:SF0; CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED; 1.
DR PANTHER; PTHR19920; WD40 PROTEIN CIAO1; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03037};
KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03037};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 54..87
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 117..158
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 163..195
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 210..255
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 295..362
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 343..365
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 365 AA; 40834 MW; 23AD50B8BCE55906 CRC64;
MAEISLSHTF KGHSDKCWST SVHKKYPLLA SVSSDKTCRL YNLNTKQLIA ILDDDTHSKA
VRTVDWKPTG DFPSLAVGSF DSTISIWGRE DEDGDEMEIS VTAATASGSE WSLMAVIEGH
ENEVKAVSWS CDGEYLASCS RDKSVWLWET DEANEEFECI NVIQDHSQDV KHVVWHPFTK
FLATSSYDDT IRLYKQDSYD YDDWINVAVL TGHQGTVWHS DFEKIDPDQG IRLCSGSDDE
TVRIWKRVSG AELSKQKNGE AIPSVVREDS HSDEWVEEAM LPKVHTGPVY SVSWNKNGLI
ASASADGRIV VYEETAKGVW RVVAVKETTH GIFEVNSIEW WSSPDGEMLV SAGDDGNVNL
WSLSL
//
