ID   W6ML66_9ASCO            Unreviewed;      1325 AA.
AC   W6ML66;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   13-SEP-2023, entry version 32.
DE   RecName: Full=REM-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=KUCA_T00001477001 {ECO:0000313|EMBL:CDK25507.1};
OS   Kuraishia capsulata CBS 1993.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetales incertae sedis; Kuraishia.
OX   NCBI_TaxID=1382522 {ECO:0000313|EMBL:CDK25507.1};
RN   [1] {ECO:0000313|EMBL:CDK25507.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK25507.1};
RA   Genoscope - CEA;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDK25507.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK25507.1};
RA   Morales L., Noel B., Porcel B., Marcet-Houben M., Hullo M-F., Sacerdot C.,
RA   Tekaia F., Leh-Louis V., Despons L., Khanna V., Aury J-M., Barbe V.,
RA   Couloux A., Labadie K., Pelletier E., Souciet J-L., Boekhout T.,
RA   Gabaldon T., Wincker P., Dujon B.;
RT   "Complete DNA sequence of /Kuraishia capsulata/ illustrates novel genomic
RT   features among budding yeasts (/Saccharomycotina/).";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
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DR   EMBL; HG793126; CDK25507.1; -; Genomic_DNA.
DR   STRING; 1382522.W6ML66; -.
DR   HOGENOM; CLU_001013_1_1_1; -.
DR   OrthoDB; 90320at2759; -.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          210..566
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          639..864
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          1055..1127
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          17..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1290..1325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          122..149
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        30..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1300..1315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1325 AA;  149321 MW;  822BF2BAEA60B259 CRC64;
     MMPDAVQSVD LSAVDDARKN PVLRRGHSAL SMQSGLQNTT GFQSMKKSES QDTPSPKLKS
     VPSLSNLNLL QSELAKQKRM RAGAEKLLRV SDVSLPSSHH TGMSFLGNQS LPAYNNTTHK
     ARMRTQSELE DANRNIITLE KKIEAMKRIQ DKETDQTTRT RSNTLATNVS DSFSDDARTP
     IDMSTTSPTW ILADILQSLG DKDNSPEFLL NKSNELVVFL QQYSSLREDL VLTSIGHRLQ
     FLLLHNLSEV VACGFRIARY ILTDLSTLSV LKSLRVDSFA IISLAKDPKY TAEREQALKL
     FRKFLEIDGG VHELSIGSFR AIVAVAETND DALRPIALET LCELALLNPQ SLYKANGLRA
     IIQSITDGPF DLSAASTATI IKMFELPLTR TYVLQEYTIS SIIAPFMDGH AKNERLQNVA
     FLLTIILKTW PGMIAFSEKS FSHLKGLISC LTYDSPSLRS IIVHVFLDIL RIRTLPWVQS
     NKTRTDSYQN FTYTITHSSK NNSRKVVLES ESSIVNQHTA LLLRASIDCG LIDKLKSVIL
     SNNDKSTRKA LLLLSEIMTL ASSLIPKEFF HERDYMAMLP LVRESEVLHK NLPTAVSFLV
     ERNVRKEGKG RYSLGMPGKP VDIINQFSKE ARSKVRYMVD DSEFKQMIAD TQVMTTKDYT
     KWNWNLLSDL ITGPLMSPRR LEETIKTTKF LKRLMSFFRP FKYRFSASRK TKSSQKYIRV
     GCEIFRMFLS CQEGVKHLSE NKLLPQIAEC LAQVDPYSGI TAADPVFSRQ KLENTACHGY
     FKMLGVLSSD PNGLQMLGQW WIYNMLYHIT ERRTGRDDLV KLFIKEMDYR YQTHLRILLR
     KVATTGDTSM RIFATNHLAN LLLIEECQDF ACSILVTQLC DPDMEVCNIA VKLLDHYCSD
     KEKILQLVKK RPSLDHLGRT AMPLLLRIMS TDVGFRYLSD INFIDSELES WIEYKNLSYI
     YEVEKLLAVE IFNVRPVLTT ASADEPSTSD TRSVPQHFFG ELVKTKSGMN ILGSTETFTS
     FCNTISSYSA RIYNEHEVEL YDTNLTSMFD QEKLILDLKA SLWAVGHIGS SDNGAIMLEI
     SGVVEDISYI CYNTLNWTLK GTCFYVLGLI AQTSEGMEIL DDLGWSTTVA ANGSPLPLCL
     PKSMSSFFNC AENGFSSQKI PADILTQSEP ESSEVAEMLN GRRSQVQLSK SSSSSVVSSL
     LGTGIPSHDM VLINSVLESL IDMLVNVSKA MTSLTKLKHK HAASFETEPA LLLLALEVLS
     KYKYKPSARR YVLLELFNYG KMMELLLKKD RKRSKEQSSY VPRKQTTGAT TIEEQHKEPS
     PTRPT
//