ID   W6MSV7_9ASCO            Unreviewed;       697 AA.
AC   W6MSV7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=KUCA_T00005436001 {ECO:0000313|EMBL:CDK29448.1};
OS   Kuraishia capsulata CBS 1993.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetales incertae sedis; Kuraishia.
OX   NCBI_TaxID=1382522 {ECO:0000313|EMBL:CDK29448.1};
RN   [1] {ECO:0000313|EMBL:CDK29448.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK29448.1};
RA   Genoscope - CEA;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDK29448.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK29448.1};
RA   Morales L., Noel B., Porcel B., Marcet-Houben M., Hullo M-F., Sacerdot C.,
RA   Tekaia F., Leh-Louis V., Despons L., Khanna V., Aury J-M., Barbe V.,
RA   Couloux A., Labadie K., Pelletier E., Souciet J-L., Boekhout T.,
RA   Gabaldon T., Wincker P., Dujon B.;
RT   "Complete DNA sequence of /Kuraishia capsulata/ illustrates novel genomic
RT   features among budding yeasts (/Saccharomycotina/).";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HG793130; CDK29448.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6MSV7; -.
DR   STRING; 1382522.W6MSV7; -.
DR   HOGENOM; CLU_011310_3_1_1; -.
DR   OrthoDB; 248389at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF100; PROTEIN MAM3; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        73..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          69..252
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          333..398
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          586..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  76222 MW;  EA38231AF660AA27 CRC64;
     MSHSRLRKSR IPKSYSRTST NDRVGLKFNT FASLVLMGLP KVVKALPIPA VELISRHVSF
     NAQKHEPLTQ SEFYVYMLSA VFLVLLGGVF AGLTLALMGQ DEVYLKVIST SGTPRERYYA
     QEVLKLVGKG KHWLLVTLLL GNVITNETLP VILDRFLGGG FLAVFSSTIA IVIFGEIIPQ
     SVSVRYGLQL GAYFAPFVVL LMYIMYPVAY PIAKLLDFIL GQDHGTLYKK SGLKTLVTLH
     KTMGVERLNQ DEVTIISAVL DLKEKSVGAI MTPIDKVYTM SSDTILNEDT VEEIFNAGFS
     RIPIHLPGEP TNFVGMLLVR VLISYDPEDS LPVSSFPLAT LPETARDTSC LNILNYFQEG
     KSHMVVVSDT PGHDTGALGV LTLEDVIEEL IGEEIVDESD VYVDLNKNIK RENPGPLSKR
     TLTTYLHTLY NSGRNLSTRN SLDSSKGVLA AHQPMYYPKR QSSDTIPSNH TMTSPSLLPV
     AGSSSAAIGH NITSTTANGI KPSNLAVNPN QTTVPNIVVK KQPALGTNVL VIPEPAVSLL
     NNEDYGSVHN NEAAAFEDDV HDNLVRKKNA EFKKFVLPEV NRNSVDLSDP RSISKGKGVI
     VPKNGNLTAS SRSSSKGDLL HLSDSDSFSH RGSGIIESVV NVKGVSKTII ESALTDNEEE
     RSDEEDSSNT DGDEAHNLMG GVNKSISMPK SRKKWRW
//