ID W6MX38_9ASCO Unreviewed; 1185 AA.
AC W6MX38;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Maintenance of telomere capping protein 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=KUCA_T00004197001 {ECO:0000313|EMBL:CDK28215.1};
OS Kuraishia capsulata CBS 1993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetales incertae sedis; Kuraishia.
OX NCBI_TaxID=1382522 {ECO:0000313|EMBL:CDK28215.1};
RN [1] {ECO:0000313|EMBL:CDK28215.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK28215.1};
RA Genoscope - CEA;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDK28215.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK28215.1};
RA Morales L., Noel B., Porcel B., Marcet-Houben M., Hullo M-F., Sacerdot C.,
RA Tekaia F., Leh-Louis V., Despons L., Khanna V., Aury J-M., Barbe V.,
RA Couloux A., Labadie K., Pelletier E., Souciet J-L., Boekhout T.,
RA Gabaldon T., Wincker P., Dujon B.;
RT "Complete DNA sequence of /Kuraishia capsulata/ illustrates novel genomic
RT features among budding yeasts (/Saccharomycotina/).";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat WDR59 family.
CC {ECO:0000256|ARBA:ARBA00038452}.
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DR EMBL; HG793129; CDK28215.1; -; Genomic_DNA.
DR AlphaFoldDB; W6MX38; -.
DR STRING; 1382522.W6MX38; -.
DR HOGENOM; CLU_001497_0_0_1; -.
DR OrthoDB; 23438at2759; -.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-KW.
DR CDD; cd16488; mRING-H2-C3H3C2_Mio-like; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR049567; WDR59-like.
DR InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46170; GATOR COMPLEX PROTEIN WDR59; 1.
DR PANTHER; PTHR46170:SF1; GATOR COMPLEX PROTEIN WDR59; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF00400; WD40; 2.
DR Pfam; PF17120; zf-RING_16; 1.
DR SMART; SM00591; RWD; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50908; RWD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 109..151
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 196..229
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 437..548
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 1131..1170
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 664..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 132781 MW; F217C38F5EAEFBB3 CRC64;
METQKGSPYD SATFGNSLSL RVDGAIGAMS LSPCGRDAVL AGRRGLFVID LDDPFAQPRW
LHHVTSWEVA DVQWSPHKSK PSWVVSTSNQ KALVWNLARS STDAIEHVLH AHDRAITDIN
FHPDNPEVLA TCSVDTFSFA WDLRTPRRPV ARWADWRSAT SQVKWNYKNP NIIASAHDNY
FYIWDMRKGA MPLEKIMAHN GRVNGLDFSR DHETEIISCS NDMTVKFWDY GESVTEPKFT
INTDFPVSRA RHVPFGDKGC GIMPAHGGNN SVYIVNYKDQ TGESKLRPGY IFKGHTEPVK
DFLWRSRHSD NTSVDDRDVQ LVTWSKDNDL RLWPVSEDIY DRFNYEKNKE LPEGTKLIDF
DYRTYRSEPV TSSDDRLKRF KKDAFVSSRG SSSRDNQFNH LDWISGVRIG QSAQAPSDSP
NAFSFGGDSL QPANLGEEVS SVGHKFPKLR FEKISVSTGQ LILSLNGPWS ATNKEDLVFL
RMEINFPKDY PSKTGKPTFN IEENQDLDSE KEKEILQNLN EISERFCGAG RHCLEQCLRS
LLGEKVSLEF DAFDENDLPL DPFDIPQAGD FNDVESMPTS LSDDSDDELV PITSTSVQTE
TDGMPFTKPA FDSTPIPKGC GAVWTASGHL VCFFIPKHEE NKPTQLKFDQ QGFTLAGTLK
KKKAGSSVGD ASSKGGRVAS SKLEDSSGES SDSDSYSSDD SFSNDLDILQ NDRPYRSAVT
GLMRKNVGLR HYTLGEAKSA TLGNASVPTE RSLGTQTSRG HNSNIVTIHD FSDLIPSKME
LAYEYRMLGD TPEKLSVHNA AVAEKYGYKD IADCWKILEV ILVKDVHLPD ILNNSDLSVV
LQHELHQKFV TDLSKVDVET NYRFYWGAHP FGSRWLARAI MEYYEKLGNI QMLAMLACIM
HEHKLHKTDP TIPIHTPYMR PPTLVNKQSV IGRFASAKGS NVGDNELEAV GNSACSSVSS
YDASGSVSFH SGSPERFGSY FKRGIGNVPP LPGVSPTNSG SRKSVVTMTS RTSSFLIPQK
SHILQGAPKV KIQMFNEVAL DLSDDVYSVP LLDPAFEEKY QMYRSQYASL LFYWGLPVNR
IKVLKFNYED SIFKNSAAVD EYRGQVGLNG YSDTHIKDLS KAKVLKEQKL CNYCSMTIKK
RLIVCTTCNH IMHADCAMQW WEGEQQTECP GGCGCICLSK KFYEH
//
