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Database: UniProt
Entry: W6N3K5_CLOTY
LinkDB: W6N3K5_CLOTY
Original site: W6N3K5_CLOTY 
ID   W6N3K5_CLOTY            Unreviewed;       617 AA.
AC   W6N3K5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=CTDIVETGP_0560 {ECO:0000313|EMBL:CDL90490.1};
OS   Clostridium tyrobutyricum DIVETGP.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1408889 {ECO:0000313|EMBL:CDL90490.1, ECO:0000313|Proteomes:UP000019482};
RN   [1] {ECO:0000313|EMBL:CDL90490.1, ECO:0000313|Proteomes:UP000019482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DIVETGP {ECO:0000313|EMBL:CDL90490.1,
RC   ECO:0000313|Proteomes:UP000019482};
RA   Soggiu A., Piras C., Gaiarsa S., Sassera D., Roncada P., Bendixen E.,
RA   Brasca M., Bonizzi L.;
RT   "Draft Genome Sequence of Clostridium tyrobutyricum Strain DIVETGP,
RT   Isolated from Cow's Milk for Grana Padano Production.";
RL   Genome Announc. 3:213-215(2015).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL90490.1}.
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DR   EMBL; CBXI010000007; CDL90490.1; -; Genomic_DNA.
DR   RefSeq; WP_017895260.1; NZ_CBXI010000007.1.
DR   AlphaFoldDB; W6N3K5; -.
DR   GeneID; 29419053; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000019482; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000019482}.
FT   DOMAIN          209..327
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          431..573
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   617 AA;  70249 MW;  D18D21F45962B1E8 CRC64;
     MKRINLLDIT TSNKIAAGEV VEKPSSVVKE LVENAIDSGA KNITIEISDG GKKLIRIIDD
     GSGIHPDDIK KAFLPHSTSK IKSIEDISKI NTMGFRGEAL ASIASVSKVT LKSRITGYDY
     GRKISIYGGK LNKIEDTACN LGTTVEVEDL FFNVPARQKF LKSSSRETAY VSDIILRLSL
     ANTDISFRLF SNGKKSINTF GTGHLIDTIR CLYGKNIYEN ITPIEKHSDI ASVSGYIGNS
     EISRGSRNNQ SIFVNKRYIK DKSITAAVER AFKSFLTINK FPFFIIFLDI FPEFIDVNVH
     PSKLEIKFTD SRMIFKFIFD AVHESLRESL KDSFTIDTEY DSEKAKIREE LVQLPIDLKP
     AEDALDKIEN YKNVTKVKEQ PIHAYRESNK GLDYSYNKID EIPEEVSKED RELSRENSET
     VKEPKFPKLR IIGQFNNTYI IGEALNTLFL IDQHAAHEKI LFEKYKNEIK NSNVISQLLI
     SPIVIELKNY DYSCYIENKD VFKNTGFNID IFGDNTISIR EVPIILGKPN IKNLFIDILD
     NLKNMGSGET WEVKYYHIAT MACKAAIKAH DKLSQIEMED LIEKLRYIED PFNCPHGRPT
     IIKFTTTDLE KKFKRIQ
//
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