ID W6NCK1_HAECO Unreviewed; 484 AA.
AC W6NCK1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 25.
DE SubName: Full=Bile acid:sodium symporter domain containing protein {ECO:0000313|EMBL:CDL94866.1};
GN ORFNames=HCOI_01302000 {ECO:0000313|EMBL:CDL94866.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Haemonchidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94866.1};
RN [1] {ECO:0000313|EMBL:CDL94866.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94866.1};
RA Aslett M.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDL94866.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94866.1};
RA Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT for drug and vaccine discovery.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL94866.1}.
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DR EMBL; CAVP010058565; CDL94866.1; -; Genomic_DNA.
DR AlphaFoldDB; W6NCK1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF28; RH04535P; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP}; Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..484
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004878880"
FT TRANSMEM 131..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 484 AA; 54764 MW; 3A232EC8EECBB822 CRC64;
MLFPFILISA LCQIFSSADP LDVVYSPESF DKFRTGETRN LTIQVTSDGT KSGEDHELIV
ECMHEDICKV IHYPSTINFS PENNHTATFE VVIESRFLGV THLNVTVGDE VLPGFPLRLL
RSDREAKVTK YFNIFLGIFI FIISTMMGTQ LEPKRIIGIA RKPIGPTIGF FCQFLGMPTI
GFLVANFGLP DDANSLKMAL FATSTCPGGG KSSFWTIIFS GNLDLSISMT FTQTLAALFM
MPLWMSTLGR HFTDAHVRIP FLRIVEGLVA FMVPTTMGMI ITHYRPQYIP CIHKWIKRVS
WCAMIVLSIF AIYSNYYIFW LITWRIVLCG CALPWLGYIT AFIVALLLRQ PFKDALTIAI
ETGIQNIGIA MLLMVWCLPE PESDIAVTII FVTAIMTDKP LVIIWLISRL YKRCCKRDIV
GQEDDDLEKR KIGEIGKREY LRHEALVIET LFFRVDNARH KRYCGQLRPH SVSAGPNAVI
TIRG
//