ID   W6NFJ7_HAECO            Unreviewed;       873 AA.
AC   W6NFJ7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Patched domain containing protein {ECO:0000313|EMBL:CDL95540.1, ECO:0000313|WBParaSite:HCON_00059670-00001};
GN   ORFNames=HCOI_01688900 {ECO:0000313|EMBL:CDL95540.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL95540.1};
RN   [1] {ECO:0000313|EMBL:CDL95540.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL95540.1};
RA   Aslett M.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDL95540.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL95540.1};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA   Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA   Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA   Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT   for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:HCON_00059670-00001}
RP   IDENTIFICATION.
RC   STRAIN=MHco3 {ECO:0000313|WBParaSite:HCON_00059670-00001};
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; CAVP010059113; CDL95540.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6NFJ7; -.
DR   WBParaSite; HCON_00059670-00001; HCON_00059670-00001; HCON_00059670.
DR   OMA; MELYMAK; -.
DR   Proteomes; UP000025227; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF85; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        262..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        672..693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        699..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        795..820
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        826..850
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          266..428
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   873 AA;  98837 MW;  3A5A31DAE9BF1BFE CRC64;
     MKDLWLTRAW VWLCRWLGHT VATWPRITII ACLLLTALFS LKAVTTQQVS SMDGWSSENA
     RSRYEYNVFQ EFLNADGQGI FVIMILRAQD NQSMIRMDYM TETIEILEFV SSQFPMYDAD
     LGRNQSFNEF CRGFCKANEP VRMFYNGLRI SEGNVSDELQ QRVNLSYPTS EMFSTKFSLL
     PNFFGVELEE DGRSIKSVSL IALLFRAERH PSWTVDAVKQ WELNIQDYFL RNYDQRRIEV
     NVLSVAIVEY DIVKAGDSLR PFLVVGFIIM CIFCTTTTIA SSVIMYHHKA TFNKVILSIT
     ACVVPFMACG TALGAIFLMG VTFSPILRIT PFLVLAISVD DSFLMIHAWN RIGKNRNEKM
     QSRSQMIAQV LVETGPAIAI SAFTNMLAFA IGSISSPFEI RVFCIGNAAC IFMDMFYQLT
     FYAAMMAIFA DSPEDPSEKE KCSRLKESTQ RLLRWYTGVV ANFRFSLMVA LIWVLFVAGA
     IMGSFYVTVD LSSRKTFLPD SKLLEIDRIR NKYMVPSYTP VTVVVSNPGD LSDAENVQGL
     IEMRNSFESL PHAIGPDSTK FLVSDYVKYK EAFQAELEED PSAGSLDAFL HWPEYSYYNG
     FIKRKNSSES NDEVEQFMFV TGYQGDELVL WSEKRRMLKL WRHEVDRFAE RFNASVFSED
     GFFIDLLEAI PLITWQSALA TFVCVIIVCA LFINDLATIL FVSMAIFATC IGVFGYMSFF
     GVTLDPIVMS ISIMCIGFSV DIPAHVSFHF HASQAHVVQR STCSTITSTS GEVSVSEKVE
     ESDFRQRLQH TLCSVGFPVI QAGLSTNLCA LPLAFVPLYM AQVFSLAMLM CISFSMIHGI
     VVLPAMFCLY DRASIAVRKW ISSMRRKSRC VPA
//