ID W6NG03_HAECO Unreviewed; 263 AA.
AC W6NG03;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Frizzled domain containing protein {ECO:0000313|EMBL:CDL96291.1};
GN ORFNames=HCOI_01763800 {ECO:0000313|EMBL:CDL96291.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL96291.1};
RN [1] {ECO:0000313|EMBL:CDL96291.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL96291.1};
RA Aslett M.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDL96291.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL96291.1};
RA Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT for drug and vaccine discovery.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL96291.1}.
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DR EMBL; CAVP010060133; CDL96291.1; -; Genomic_DNA.
DR AlphaFoldDB; W6NG03; -.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 1..98
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 118..234
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 30..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 61..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 263 AA; 30238 MW; 80CB7A9EB99F7B08 CRC64;
MRLPNLLEHD TINEAIHQSS DWKSLLQLNC HPDTQLFLCS LFAPICLPTM DKEILPCRSL
CKAVKQGCEG RMSVYGFPWP EMLSCDKYPE DNDMCIKAMN VEKQGKLARP MHARDISCPA
CVQVGTFENL VDHFCRSQLV LKAKIARITG THVSLRNARS LKKGDRRRLV EDTDVRLSAD
SNGCPCNVTD NGDRRYLVMA SKGNDGQFTA NLILPWKKDK NFKRAIHQFQ RLNCKSLGRE
IRESASRRPH YYSMRRHNQK RLF
//
