ID W6NQ75_HAECO Unreviewed; 787 AA.
AC W6NQ75;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Uridine 5'-monophosphate synthase {ECO:0000256|ARBA:ARBA00015047};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN ORFNames=HCOI_00851100 {ECO:0000313|EMBL:CDL94352.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Haemonchidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94352.1};
RN [1] {ECO:0000313|EMBL:CDL94352.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94352.1};
RA Aslett M.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDL94352.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94352.1};
RA Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT for drug and vaccine discovery.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC TatD-type hydrolase family. {ECO:0000256|ARBA:ARBA00009275}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OMP decarboxylase
CC family. {ECO:0000256|ARBA:ARBA00009769}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the purine/pyrimidine
CC phosphoribosyltransferase family. {ECO:0000256|ARBA:ARBA00006221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL94352.1}.
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DR EMBL; CAVP010058281; CDL94352.1; -; Genomic_DNA.
DR AlphaFoldDB; W6NQ75; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd01310; TatD_DNAse; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018228; DNase_TatD-rel_CS.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR014732; OMPdecase.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR001130; TatD-like.
DR NCBIfam; TIGR00336; pyrE; 1.
DR NCBIfam; TIGR01740; pyrF; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF01026; TatD_DNase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR PROSITE; PS01090; TATD_2; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:CDL94352.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Transferase {ECO:0000313|EMBL:CDL94352.1}.
FT DOMAIN 558..775
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 787 AA; 87597 MW; D5D37DADC245EA57 CRC64;
MSTEAIERVV PYELVDIGAN LGHPSFKNDL NDILIRARQS GISKLMITGT CEKISKEAME
LAETMPGFLY FTAGVHPHDA KDFDAKTLDT LRSLQAHAQC VAVGECGLDF NRNFSPPDTQ
KEVFVFWVEL ACELQKPLFI HEREAHEDMV RILSNAGERL PPAVIHCFTG TEDEAKKYIE
MGLYIGLTGF LWKDRLTNGV QVALRNGSIP LDRLLIETDA PFMYPKISDK KLPADVKEAF
TEPTKQLHKF TSFNRNEPCA LAAVCEMIAA FMGRDPKEVA EVTTTNAKRV YDILMNMLVE
ESMNGARQRN LLRYMLNSKV FKFGDFELKS GMRSPIYIDL RECFGYSDIM DLASDGLKSV
IEKADILVDG IVGVPYAALP YATLVSCRIR KPLIIVRKEA KDHGTKKMIE GLYQKGNRVV
IIEDVVTTGG SVKEVVKTLR GVGLVVEDVF CLLNREQGGP EKLEEEGITL HSLFNMETVL
SFLLSVDAID KETSLGIIEA LNLPFKEVKR FEISPEMENL ASFPMSNLGR LPIEERAKEA
MCSMNKRIFS LMLKKNSNLC LAVDYTEAEK ILELVDKAGP FVVAVKVHAD AIVDFSKEFT
TRLVRLANDH DFVIFEDRKF GDTGNTNLLQ LKGALRVAEW ADVVTVHIVQ GCDSIGSVFR
QVILDPAYRL SGVLLIAQLS TKGSLTALPG YTEAAAEMGE ANRDVVCGFI CQARVSPHPD
MLHWTPGVNL DSTSDNKGQQ WRGVDEAIGR QQNDIVIVGR GVTASANPIQ ELTRYREQAW
SALVLKN
//