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Database: UniProt
Entry: W6NQ75_HAECO
LinkDB: W6NQ75_HAECO
Original site: W6NQ75_HAECO 
ID   W6NQ75_HAECO            Unreviewed;       787 AA.
AC   W6NQ75;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Uridine 5'-monophosphate synthase {ECO:0000256|ARBA:ARBA00015047};
DE            EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE            EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN   ORFNames=HCOI_00851100 {ECO:0000313|EMBL:CDL94352.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Haemonchidae; Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94352.1};
RN   [1] {ECO:0000313|EMBL:CDL94352.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94352.1};
RA   Aslett M.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDL94352.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94352.1};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA   Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA   Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA   Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT   for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       TatD-type hydrolase family. {ECO:0000256|ARBA:ARBA00009275}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the OMP decarboxylase
CC       family. {ECO:0000256|ARBA:ARBA00009769}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the purine/pyrimidine
CC       phosphoribosyltransferase family. {ECO:0000256|ARBA:ARBA00006221}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL94352.1}.
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DR   EMBL; CAVP010058281; CDL94352.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6NQ75; -.
DR   UniPathway; UPA00070; UER00119.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04725; OMP_decarboxylase_like; 1.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   CDD; cd01310; TatD_DNAse; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   HAMAP; MF_01208; PyrE; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR018228; DNase_TatD-rel_CS.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR014732; OMPdecase.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR023031; OPRT.
DR   InterPro; IPR004467; Or_phspho_trans_dom.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR001130; TatD-like.
DR   NCBIfam; TIGR00336; pyrE; 1.
DR   NCBIfam; TIGR01740; pyrF; 1.
DR   PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   Pfam; PF01026; TatD_DNase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS01090; TATD_2; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000313|EMBL:CDL94352.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Transferase {ECO:0000313|EMBL:CDL94352.1}.
FT   DOMAIN          558..775
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|SMART:SM00934"
SQ   SEQUENCE   787 AA;  87597 MW;  D5D37DADC245EA57 CRC64;
     MSTEAIERVV PYELVDIGAN LGHPSFKNDL NDILIRARQS GISKLMITGT CEKISKEAME
     LAETMPGFLY FTAGVHPHDA KDFDAKTLDT LRSLQAHAQC VAVGECGLDF NRNFSPPDTQ
     KEVFVFWVEL ACELQKPLFI HEREAHEDMV RILSNAGERL PPAVIHCFTG TEDEAKKYIE
     MGLYIGLTGF LWKDRLTNGV QVALRNGSIP LDRLLIETDA PFMYPKISDK KLPADVKEAF
     TEPTKQLHKF TSFNRNEPCA LAAVCEMIAA FMGRDPKEVA EVTTTNAKRV YDILMNMLVE
     ESMNGARQRN LLRYMLNSKV FKFGDFELKS GMRSPIYIDL RECFGYSDIM DLASDGLKSV
     IEKADILVDG IVGVPYAALP YATLVSCRIR KPLIIVRKEA KDHGTKKMIE GLYQKGNRVV
     IIEDVVTTGG SVKEVVKTLR GVGLVVEDVF CLLNREQGGP EKLEEEGITL HSLFNMETVL
     SFLLSVDAID KETSLGIIEA LNLPFKEVKR FEISPEMENL ASFPMSNLGR LPIEERAKEA
     MCSMNKRIFS LMLKKNSNLC LAVDYTEAEK ILELVDKAGP FVVAVKVHAD AIVDFSKEFT
     TRLVRLANDH DFVIFEDRKF GDTGNTNLLQ LKGALRVAEW ADVVTVHIVQ GCDSIGSVFR
     QVILDPAYRL SGVLLIAQLS TKGSLTALPG YTEAAAEMGE ANRDVVCGFI CQARVSPHPD
     MLHWTPGVNL DSTSDNKGQQ WRGVDEAIGR QQNDIVIVGR GVTASANPIQ ELTRYREQAW
     SALVLKN
//
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