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Database: UniProt
Entry: W6NQU0_HAECO
LinkDB: W6NQU0_HAECO
Original site: W6NQU0_HAECO 
ID   W6NQU0_HAECO            Unreviewed;       513 AA.
AC   W6NQU0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 16.
DE   SubName: Full=Aldehyde dehydrogenase domain containing protein {ECO:0000313|EMBL:CDL94567.1};
GN   ORFNames=HCOI_02173500 {ECO:0000313|EMBL:CDL94567.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL94567.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|EMBL:CDL94567.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94567.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Aslett M.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDL94567.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL94567.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDL94567.1}.
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DR   EMBL; CAVP010058389; CDL94567.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227}.
FT   DOMAIN       37    494       Aldedh. {ECO:0000259|Pfam:PF00171}.
SQ   SEQUENCE   513 AA;  55092 MW;  FBD918AF26833729 CRC64;
     MASFLINDGK YAFLKELGLS ENNCGVFHGK WSASGPVVQS VCPANNQPIA NVQNGTVADY
     EVAVQEARKA YEHWCEVPAP RRGEVVRQIG DKLRSQLQNL GKLVSMEMGK ISAEGVGEVQ
     EYVDICDYAT GLSRSLSGTI LPSERPGHAL LEQWNPLGVV GVISAFNFPC AVYGWNNALA
     LVTGNSVIWK PAPSTPLTAI AVTKLVEGVL RANDLPGGLC SLVCGEGDVG QALVKDKRVN
     LVSFTGSTEV GRIVGQQVQQ RFGKLLLELG GNNAIIVNDD ADINMVVPAT VFAAVGTAGQ
     RCTTTRRLFV HEAVYDTVLD RVKRAYAQFE SRIGDPLEPN TIIGPLHNEV AVMKYKATVA
     EAIATGGKVE YGGKVLEREG NFVLPTIITG LPHDAPVILR ETFAPIMYVI KVKNLDDAIK
     YNNEASQGLS SSLFTNNIQN VFKWMGPKGS DCGIVNVNIP TSGAEIGGAF GGEKETGGGR
     ESGSDSWKQY MRRSTCTINF SKDLPLAQGI KFE
//
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