ID W6NYS4_HAECO Unreviewed; 636 AA.
AC W6NYS4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Tyrosine protein kinase and Sterile alpha motif homology 2 domain containing protein {ECO:0000313|EMBL:CDL96932.1};
DE Flags: Fragment;
GN ORFNames=HCOI_00911700 {ECO:0000313|EMBL:CDL96932.1};
OS Haemonchus contortus (Barber pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6289 {ECO:0000313|EMBL:CDL96932.1};
RN [1] {ECO:0000313|EMBL:CDL96932.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL96932.1};
RA Aslett M.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDL96932.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDL96932.1};
RA Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D., Devaney E.,
RA Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I., Li K.,
RA Morrison A.A., Reid A.J., Sargison N., Saunders G., Wasmuth J.D.,
RA Wolstenholme A., Berriman M., Gilleard J.S., Cotton J.A.;
RT "The genome and transcriptome of Haemonchus contortus: a key model parasite
RT for drug and vaccine discovery.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL96932.1}.
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DR EMBL; CAVP010058316; CDL96932.1; -; Genomic_DNA.
DR AlphaFoldDB; W6NYS4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:CDL96932.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:CDL96932.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..491
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CDL96932.1"
SQ SEQUENCE 636 AA; 70519 MW; BB6FE1C366FA5E71 CRC64;
VSKFTDAPAY RVVDLRTAPL TRYVVSGLRV ESEQKDGITL AWLSPAVSKK VKYEVRVNVD
GWGVWSDPLW YELGRGLVQQ HQGPETTPLG AVPGWVVLMT MILFVLLLAF LVVLCRRKRH
NRKQMSDLDV LDTYKQDTMT PDYSSGNRQF TDAFRSGKLN APLIPSYGGS SVSQPPPYYG
SGGAAATFKP YVDPTAYEDP NQALVEFTFD IDPAAVFITE VIGGGEFGDV CKGGLKRNMV
GGGIANSIFD NEIDVVAIKT LKPGSSAKAK ADFLLEASIM GQFAHPNVIR LIGVVTRSEP
AMIVTEYMSN GSLDHLLRGK DARGEEMGWP RLVDMMRGIA SGMKYLTDKG YVHRDLAARN
VLVDSELTCK IADFGLSRGV DDSAEQEYTT NGGKIPVRWT SPEAITHRKF TAASDVWSFG
VLVWEVCSFG ERPYWDWTNQ KVISEIMLGY RLPAPMDCPA ALHRLMLWCW RLDRHERPTF
AQILAILEKY VRNPDLIYVD TAAFTSGRLA TSTANINGNA FGHPTGSPGG PMIPNIHPSS
LPTLADFLRS LNLSHCTEKL NKEGIFTVTD LARRSHLDML AMGLISEEFQ RIRSALSQLQ
DSRGTFQMDS DMLEHRETGV TGKDAERKCC FIFLFT
//
