ID   W6PU43_PENRF            Unreviewed;       817 AA.
AC   W6PU43;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=AMP-dependent synthetase/ligase {ECO:0000313|EMBL:CDM27395.1};
GN   ORFNames=PROQFM164_S01g001206 {ECO:0000313|EMBL:CDM27395.1};
OS   Penicillium roqueforti (strain FM164).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM27395.1};
RN   [1] {ECO:0000313|EMBL:CDM27395.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM164 {ECO:0000313|EMBL:CDM27395.1};
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
CC   -!- SIMILARITY: Belongs to the NRP synthetase family.
CC       {ECO:0000256|ARBA:ARBA00029454}.
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DR   EMBL; HG792015; CDM27395.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6PU43; -.
DR   STRING; 1365484.W6PU43; -.
DR   OMA; VAIDMEP; -.
DR   OrthoDB; 3305653at2759; -.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   CDD; cd05918; A_NRPS_SidN3_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:CDM27395.1}.
FT   DOMAIN          283..620
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   817 AA;  90041 MW;  B22E36A4D238EEFA CRC64;
     MAPVLFEPTI VSQLSTAPLK VAVNDVSTDR VNLTLKVRPW RLLHLADALN LPPLAAQEED
     PDIHIQRLLQ LAWITTIRAF CCSTTLYIGQ DYPKGQCYIG EAAHGYSKPT VQIHVDPHDT
     VGDLFRESIE ALVPLSHMGV TKEVHTDQVG ENSSFNVTIF YQKQPAESTL SNQCMDGFQV
     CCGAPAREST EVDSFPGLQL SISHTSDDML HARLDVGNTD IGLPMATSLL HSFNRALSSI
     DGSSTQTIGS LELCSPQDRE QITLFTGAIG PTHDSLLHDL CLQHAKTTPD APAVRSWDGD
     LTYRRLEELT SRLAHWLVGQ GVGPNIYVAC AFYKSTWAIV ARLAVLKAGG AYICVDGSDP
     PPYLSSVLER TQIKIMLTSE GYKGRFGDRI ETLFEVSDAS VSSLPLVTSV PCSTVTPTDP
     CVVLFTSGST GSPKGIIQEH RSYASALTDY IRVMDMGPHS RMFQFDSYTF DISNNDFLAP
     LIAGGCCCVP TKSLTMESLM NDMNDLEGNI MFITPSVAID MEPDRVPTLE MMCIGGEPVS
     DAVLAKWLGR VQVVNQYGMG EVASLCTYNR NLQMGRGSVV GRPATGTIWI VNPDNPDQLM
     PVGAVGELLI EGPHLSRGYL DHVSGKSENF LSTPPVWMAR LHPERPNHRL YRSGDLGRYN
     HDGTIELMGR KDSMLKLDGA RVEAGQVEYV LRRNLSTGDF AVVDVLGAID GQGDPILAVF
     LYLTNNPMNM ESGPVEEMEF RPISERHAVH ALTQSLSDAV RQTLPKYYVP GLYILIDRVP
     RTRSKKTDRR KLHMLGQAYY MKYRDVLEGI TVWLDWI
//