ID   W6Q2F2_PENRF            Unreviewed;      1368 AA.
AC   W6Q2F2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Ribonuclease II/R {ECO:0000313|EMBL:CDM30490.1};
GN   ORFNames=PROQFM164_S02g000639 {ECO:0000313|EMBL:CDM30490.1};
OS   Penicillium roqueforti (strain FM164).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM30490.1};
RN   [1] {ECO:0000313|EMBL:CDM30490.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM164 {ECO:0000313|EMBL:CDM30490.1};
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
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DR   EMBL; HG792016; CDM30490.1; -; Genomic_DNA.
DR   STRING; 1365484.W6Q2F2; -.
DR   OMA; QIQATHQ; -.
DR   OrthoDB; 945235at2759; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR041093; Dis3l2_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17877; Dis3l2_C_term; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
PE   4: Predicted;
FT   DOMAIN          750..1083
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          499..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1194..1249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1265..1314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..514
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..642
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1218..1236
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1265..1289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1368 AA;  151096 MW;  26C9777C8AD69DA3 CRC64;
     MDQQSQSGPQ GPGGRKFHIA HRRSPSELTP LMMEQLAIQQ QIELLQQQQQ QIAATHQQYV
     NMGLLQPQQL GQVPSFQPGA SMGGVSPQQV NAFQFPQGGQ QQQLGVPMNV PNQHSHRRNQ
     SALPGLPMGP PPAPSSGASG YADYNQQGQN NNNHKNENAG RGRGGPPGGG HQRRHSLALP
     EAKKAAELAQ QKRTASGFQF PAPAPGAGSS DNQSSSDDKP VSTSPAPQGP AFQRAGNMRA
     GGHGRSQSMA IGGNRAAISG RGAGGFQFPQ ASEPVTNQSD NQRRPSQNGG HARSSSRNFE
     GNWRQPNNQN QSQDQQRPIG QQQGGFQPGH RSRGSMNQSM GSIGQFQYGG QPQLGQPQLI
     QLPQGQVMMA PQMFGNQQLN PLQLAQFQAL QQNAQSMGGL QASQHAPPQM SVQQQQQQQR
     KTLFTPYLPQ ANLPALLSNG QLVAGVLRVN KKNRSDAYVT TDDLDADIFI CGSKDRNRAL
     EGDYVAIELL DVDEVWGQKK EKEEKKKRKD ITDARSNSTA GNDKLGRSDS AGDRQEIGPD
     GSIRRRGSLR QRPTQKKNDD VEVEGQSLLL CEEDEISDEQ KPLYAGHVVA VIERVAGQMF
     SGTLGLLRPS SQATKEKQEA ERQARDGAHG RSHNDRHQDK PKIVWFKPTD KRVPLIAIPT
     EQAPRDFVEK HQDYANRIFV ASIKRWPITS LHPFGTLVEQ LGEMGDLRVE TDALLRDNNF
     GSDDFSDAVL KSIGWEDWSV SSEGDALASR RDFREETIFT IDPADSKSLE DAFHVKSLAD
     GKVEIGVHVA DIAHFVKGNS LVDREAKKRG TAVYLVDRIM NMLPTRVSTE LCSLVPGEDR
     LTVSVVFKAN PTTGVVDEDV WIGKGVIKSA GRLDYDQVNA LVQDKSDVNT SGISADSIRL
     LHNIVAKFRE ARFGNRVSNV PVQRLLQQLD DENVPVEYNI FESTPAHELV EELSHQANFF
     VARKLVSAMP ERAFLRRQFS PNSRRLTLFV ERMNRLGFEM DSSSSGSLQS SLCKVEDVDL
     RKGMETLIAK AMQRAKYYVS NGAPDEMRQH YMLNVPVYTH FTNPSRRYAD ILVHRQLEAV
     LSGGAVEFND DIESLNKTAD LCNNKKDSAL NAQEQSVHIE ACRKMDRKSR EIGGDLISEG
     IVLCVYESAF DVLIPEYGFE KRVHCDQLPL KKAEYRKDSR VLELYWEKGV PSSAYIPEDE
     RPKPGNSRAA QAAAAARDAE AARERARERD EAMRKQTETG TMSADDVDAL FDDDEDADEV
     TEMTAGVSLN SADRSTQSMP PSPTRNGHHQ QAPHRTRSDP KIASGTGDAP ENKLTNKEKY
     LNLFKLREVD GEFIQDVTEM TRVPIILKTD LSKSPPCLTV RSVNPYAL
//