ID W6Q4J6_PENRF Unreviewed; 611 AA.
AC W6Q4J6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Six-bladed beta-propeller, TolB-like {ECO:0000313|EMBL:CDM30876.1};
GN ORFNames=PROQFM164_S02g001026 {ECO:0000313|EMBL:CDM30876.1};
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM30876.1};
RN [1] {ECO:0000313|EMBL:CDM30876.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164 {ECO:0000313|EMBL:CDM30876.1};
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
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DR EMBL; HG792016; CDM30876.1; -; Genomic_DNA.
DR AlphaFoldDB; W6Q4J6; -.
DR STRING; 1365484.W6Q4J6; -.
DR OMA; RCAFDGS; -.
DR OrthoDB; 4517707at2759; -.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF10; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10070)-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
FT DOMAIN 23..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 199..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 611 AA; 66955 MW; BEDEAAEC4099B065 CRC64;
MNTLRRSMAS HWVPPSNYRN RPVTILGAGV LGRRIGCIWA SAGYDVRIRD PSSQQRADGI
AYIQENVQSY AAKTKQIPGS FEAFEDMKKA VENAWLVIEA VPEKLELKIS TFAELEALAP
EDCILASNSS SYKSSEIISQ ISDATKKRVL NMHYYMPPSC MIVELMTDGH TAPEIFPFMV
ERSKEAATSP YVARKESTGF IFNRLWAAVK REVMTILAEG VSVPEEIDSM WNELFIKGKS
LPCRTMDNVG LDTVAFIESH YVQERGLSPE KTVDFLKANY LDQGKLGTKC SKGGLYPASE
STSTPKTPDL LVLDIGLSAI KPGVTSGEIV RFAADGTLKN VVLKDQSLPD GLIIDPISGR
MFWTCMGAPG KFDGGVYSAN VDGTDIKTLI APGTINTPKQ IVLHSEAKTV YFCDREGCRV
YRCAYDGSNL EVLIDNTGGE ANPQHRISDW CVGIAVVPNY GKFYWTQKGP SKAGKGRIFC
ANITTPEGES PDARSDVQVV LADLPEPIDL EVHEATHTLY WTDRGELPIG NSLNKAQLSE
QGLLLPASSA LGYDVITRNL NEAIGLILDP ANSQIYLTDL GGSIYRTDMD GNNKEKIYSN
DDRAFTGIAL V
//
