ID W6Q5U8_PENRF Unreviewed; 610 AA.
AC W6Q5U8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Methylenetetrahydrofolate reductase 1 {ECO:0000313|EMBL:CDM31695.1};
GN Name=met9 {ECO:0000313|EMBL:CDM31695.1};
GN ORFNames=PROQFM164_S02g001846 {ECO:0000313|EMBL:CDM31695.1};
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM31695.1};
RN [1] {ECO:0000313|EMBL:CDM31695.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164 {ECO:0000313|EMBL:CDM31695.1};
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; HG792016; CDM31695.1; -; Genomic_DNA.
DR AlphaFoldDB; W6Q5U8; -.
DR STRING; 1365484.W6Q5U8; -.
DR OMA; VARTSQW; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 610 AA; 68788 MW; F52235C6B5D5AA90 CRC64;
MHIREKLAKN EAEGKIGISF EFFPPKTAQG VQNLYDRMDR MHGLGPSFID ITWGAGGRLS
DLTCEMVSVA QSVYGLETCM HLTCTDMPLE KVDQALQAAY KAGCTNILAL RGDPPRDKET
WEATDNGFCY AKDLVKYIRD KYGNHFDIGV GGYPEGADDN TDVDQLIDHL KEKVDAGSSF
VVTQMFYDAD NFIEWVKKCR AKGITVPIIP GIMPIQTYAS FIRRSNWTKV KVPSEWMEAL
EPVKNDDSAV REIGKTLIAN MCRQLVTAGI KHLHFYTMNL AQATQLVLKE LDLCPSDDSP
IQRALPWRPS LGLGRRTEDV RPVFWRNRNS SYVARTQTWD EYPNGRWTDS RSPAFGELDA
YGVGLKGTNE QNIKLWGEPK SIKDISDIFV KFLTGKLDRL PWSDSPITTE AREIQEDLLN
LNQRGFLTIN SQPAVNGVKS CHPVHGWGPK NGFVYQKAYL ELLVPSNLID ELITRIEKND
DLTYHATNKK GELRTNTRDS PNALTWGIFA GREIIQPTIV ETVSFLAWKD EAYLLGEHWS
KCYDAASPSR KLIHQVMDDW YLVNIVDNDF HRSNAVFELF NGLEVKDLNV ELPGVPLDNG
NAEQNGVAAN
//
