ID W6QN91_PENRF Unreviewed; 496 AA.
AC W6QN91;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Multi antimicrobial extrusion protein {ECO:0000313|EMBL:CDM37426.1};
GN ORFNames=PROQFM164_S06g000388 {ECO:0000313|EMBL:CDM37426.1};
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM37426.1};
RN [1] {ECO:0000313|EMBL:CDM37426.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164 {ECO:0000313|EMBL:CDM37426.1};
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR EMBL; HG792020; CDM37426.1; -; Genomic_DNA.
DR AlphaFoldDB; W6QN91; -.
DR STRING; 1365484.W6QN91; -.
DR OMA; EFWILLK; -.
DR OrthoDB; 661905at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206:SF113; MATE EFFLUX FAMILY PROTEIN (EUROFUNG); 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 53574 MW; 4BA09186614A6D6D CRC64;
MPNPSSNGGS SHQPTEYTSL LAKPIDNGPP LHDSEDESPF SRALILAEFW LLLKDSTPVI
LAYTLQNSLQ TISVLIIGRS SPENLAASAF SQMFAMVTGW MIALGGTTAM DTLASSTFTG
SSNKHDLGIL LQRGFLVLGL FYIPVAILWA CSEPVFLFLG QSPQLSHDSA RFLTCLIPGG
LGYIYFEVMK KYLQAQGIMR AGTYVLLITS PLNAGLNYLF CYTFKIGLLG APLATGICYW
LSFALLVLYA RFINGAECWG GWSREAFQNL RTFARLALLG IVHVGTEWWA FEIVALAAGH
LGTVSLAAQS VIMTADQVLN TIPFGIGVAT SGRVGNLLGK RDDTGAARAA HTSAVLSMVC
GGVVLAVLIG TRDHFAKIFN DDSDVVRLTA EVMPYVALFQ IADGLNGSCG GSLRGMGRQH
VGALVNLVSY YCGALPLGIW LAFHGWGLKG LWVGQCIALY LVGVFEWVIV ARSRWDVEVQ
KAFQRMDVHE TLEDAI
//
