ID   W6QPP1_PENRF            Unreviewed;       577 AA.
AC   W6QPP1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Cobalamin (Vitamin B12) biosynthesis CobW {ECO:0000313|EMBL:CDM31547.1};
GN   ORFNames=PROQFM164_S02g001697 {ECO:0000313|EMBL:CDM31547.1};
OS   Penicillium roqueforti (strain FM164).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM31547.1};
RN   [1] {ECO:0000313|EMBL:CDM31547.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM164 {ECO:0000313|EMBL:CDM31547.1};
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
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DR   EMBL; HG792016; CDM31547.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6QPP1; -.
DR   STRING; 1365484.W6QPP1; -.
DR   OMA; WSQAGPN; -.
DR   OrthoDB; 50694at2759; -.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   Pfam; PF02492; cobW; 2.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          317..492
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
FT   REGION          347..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..381
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  65453 MW;  7B4E3D7DF222F9B3 CRC64;
     MVINSGTDSV SYNVPAPLEE KPKTRQMPVT LLSGFLGSGK TTLLKHILKS PDHGLRIAVI
     VNDMSQLNID ATLIQNHKVS QTTEKLIRLQ NGCICCTLRG DLLAELAALT KRNEVDYVII
     ESTGISEPMQ VAETFTSEFS SAMLEAEDQI ANDDEEARKI LDEIVNLGGL HTMARLDTTV
     TVIDAFNLLS SFDTAEFLSD RYGREEIVPE DERTISDLMV DQIEFADVLI LNKVETVDQA
     TRDKLMHLLK LLNPVAKILE SNYSQIDVRE IINTNKFDFV RAASGPGWLQ SLHEMTIQTT
     GNGERLAPKP ETLEYGINNF VYTARRPFHS RRLFALLHDK FIILQNNEVE EEEGDEEDGE
     EDEEEEEEDA MDTDSDSGSV EDFDQPDPAV IMSNKRNHPA FGPVLRSKGF FWLTTRPWQF
     GEWSQAGGML TLGCGGPWFA ELPDEAWPED KDVRESIQND FQGAWGDRRQ EIVFIGEGID
     TGKITALLDE CLLDDKDMKK WEKVMKNKKM SRDEKTDKLA KMWEDGWEEW PAFEVEEEEE
     EEEEQEPEQG KHRISEYLGQ KKGTKHAHGH NHRMVAA
//