ID W6QU04_PENRF Unreviewed; 522 AA.
AC W6QU04;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Fructose-2,6-bisphosphatase {ECO:0000313|EMBL:CDM37624.1};
GN ORFNames=PROQFM164_S06g000586 {ECO:0000313|EMBL:CDM37624.1};
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM37624.1};
RN [1] {ECO:0000313|EMBL:CDM37624.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164 {ECO:0000313|EMBL:CDM37624.1};
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
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DR EMBL; HG792020; CDM37624.1; -; Genomic_DNA.
DR AlphaFoldDB; W6QU04; -.
DR STRING; 1365484.W6QU04; -.
DR OMA; VKTHVFH; -.
DR OrthoDB; 2013830at2759; -.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR PANTHER; PTHR10606:SF39; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 45..247
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REGION 466..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 60130 MW; 8043CBACB734AD5D CRC64;
MDTLLTAEIV ANSPRFRRKS SIFVDAIHDL PEKADLAPAQ LYSTESGRLF HSGRIVIITV
GLPARGKTHI SVALARYLRW LGVKTRIFHL GDYRRATIPF GEDMPDDYFY VNATAKSVLL
RQKIVRKCRE DIYHFLNHEN GQIAIYDAVN PLTLFIESWC DDERIIEENV RRVKISSPDY
VSWKSEDAVK HYLNRIYSRI PQFQTMEEKD LNFIKMINAG ERLIVNNRSF GYLSNRIVFY
LLNLHIKSRR TYFARAGVSL DAGSYKADTS LSDQGEDYAK KMTARLLAHR EEEKQAMIER
GETGYESRPL KVWTSTRRRT VETAKYFHEN GYKVRQRSQL SQLNPGVCEK MSEDRIRAEF
GDEVAKHELD PYHHRYPRAE SYHDLAVRLE PIILELEREQ TDLLIIAHES VLRVLYGYLM
ACNAADIPFL EFPRDEIIEI LPESYQNEAQ RIHIPDLPEE IIPASPEDLK IPVPPSGVVS
PAQGLGSPDG QVTPQSGHRT PSGIRTPRER ERISQQHVED VV
//
