ID W6RVX5_9CLOT Unreviewed; 327 AA.
AC W6RVX5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=RluA family pseudouridine synthase {ECO:0000313|EMBL:CDM68508.1};
DE EC=5.4.99.- {ECO:0000313|EMBL:CDM68508.1};
GN ORFNames=CM240_1349 {ECO:0000313|EMBL:CDM68508.1};
OS Clostridium bornimense.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1216932 {ECO:0000313|EMBL:CDM68508.1, ECO:0000313|Proteomes:UP000019426};
RN [1] {ECO:0000313|EMBL:CDM68508.1, ECO:0000313|Proteomes:UP000019426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M2/40 {ECO:0000313|Proteomes:UP000019426};
RA Wibberg D., Puehler A., Schlueter A.;
RT "Complete genome sequence of Clostridum sp. M2/40.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876}.
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DR EMBL; HG917868; CDM68508.1; -; Genomic_DNA.
DR RefSeq; WP_044037601.1; NZ_HG917868.1.
DR AlphaFoldDB; W6RVX5; -.
DR STRING; 1216932.CM240_1349; -.
DR KEGG; clt:CM240_1349; -.
DR PATRIC; fig|1216932.3.peg.1343; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_1_0_9; -.
DR OrthoDB; 9807829at2; -.
DR Proteomes; UP000019426; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR21600:SF92; 21S RRNA PSEUDOURIDINE(2819) SYNTHASE; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:CDM68508.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019426};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 12..78
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 327 AA; 37882 MW; D545F5D3B081CA6A CRC64;
MIINISSNES GQRLDKFLKK YLKNIPLNGI YKHIRKKDIR VNGEKSAENY ILQEGDVVEL
NKYVRIDGLK EIKEEKVKRF TSIDSSSLKI TYEDKNILVV EKWPGVLVHQ DSREGEATLT
DYVLSYLNEK GDYKPENEIT FTPAPCNRLD RNTSGIVVFG KSYEGLKGIN KIIRENNIRK
YYIALVKGKI EEGLHEAYIK KNEENNISKV YREPGKDRKK IAMDVKVLET VGAYSLLDIN
LITGRSHQLR AHLAELGNPI IGDPKYGDRK LNSYFDNKYA LKFQYLYAYK LIFKNLDDTL
SYLENKTIVE TLPPIFKKIK KDVLRFN
//
