UniProt: W6S2U9

Database: UniProt
Entry: W6S2U9_9CLOT

LinkDB:  W6S2U9_9CLOT 
Original site:  W6S2U9_9CLOT

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (2)   
All databases (16)   

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ID   W6S2U9_9CLOT            Unreviewed;       528 AA.
AC   W6S2U9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Nitrogenase protein alpha chain {ECO:0000256|RuleBase:RU004022};
DE            EC=1.18.6.1 {ECO:0000256|RuleBase:RU004022};
GN   Name=nifD {ECO:0000313|EMBL:CDM70239.1};
GN   ORFNames=CM240_3122 {ECO:0000313|EMBL:CDM70239.1};
OS   Clostridium bornimense.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1216932 {ECO:0000313|EMBL:CDM70239.1, ECO:0000313|Proteomes:UP000019426};
RN   [1] {ECO:0000313|EMBL:CDM70239.1, ECO:0000313|Proteomes:UP000019426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M2/40 {ECO:0000313|Proteomes:UP000019426};
RA   Wibberg D., Puehler A., Schlueter A.;
RT   "Complete genome sequence of Clostridum sp. M2/40.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16
CC         ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16
CC         phosphate; Xref=Rhea:RHEA:21448, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC         COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17997,
CC         ChEBI:CHEBI:18276, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=1.18.6.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000805,
CC         ECO:0000256|RuleBase:RU004022};
CC   -!- COFACTOR:
CC       Name=[8Fe-7S] cluster; Xref=ChEBI:CHEBI:21143;
CC         Evidence={ECO:0000256|ARBA:ARBA00001919};
CC   -!- SIMILARITY: Belongs to the NifD/NifK/NifE/NifN family.
CC       {ECO:0000256|RuleBase:RU004021}.
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DR   EMBL; HG917869; CDM70239.1; -; Genomic_DNA.
DR   RefSeq; WP_044040375.1; NZ_HG917869.1.
DR   AlphaFoldDB; W6S2U9; -.
DR   STRING; 1216932.CM240_3122; -.
DR   KEGG; clt:CM240_3122; -.
DR   PATRIC; fig|1216932.3.peg.3090; -.
DR   eggNOG; COG2710; Bacteria.
DR   HOGENOM; CLU_025876_1_1_9; -.
DR   OrthoDB; 9767044at2; -.
DR   Proteomes; UP000019426; Chromosome 2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0018697; F:carbonyl sulfide nitrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016163; F:nitrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12380; Nitrogenase MoFe cofactor biosynthesis protein NifE, C-terminal; 1.
DR   Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 2.
DR   InterPro; IPR000510; Nase/OxRdtase_comp1.
DR   InterPro; IPR010143; Nase_comp1_asu.
DR   InterPro; IPR000318; Nase_comp1_CS.
DR   NCBIfam; TIGR01862; N2-ase-Ialpha; 1.
DR   PANTHER; PTHR43457; NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN; 1.
DR   PANTHER; PTHR43457:SF1; NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN; 1.
DR   Pfam; PF00148; Oxidored_nitro; 1.
DR   SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
DR   PROSITE; PS00699; NITROGENASE_1_1; 1.
DR   PROSITE; PS00090; NITROGENASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU004022};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004022};
KW   Nitrogen fixation {ECO:0000256|ARBA:ARBA00023231,
KW   ECO:0000256|RuleBase:RU004021};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU004022};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019426}.
FT   DOMAIN          49..499
FT                   /note="Nitrogenase/oxidoreductase component 1"
FT                   /evidence="ECO:0000259|Pfam:PF00148"
FT   COILED          402..429
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   528 AA;  59258 MW;  83689D98E0240431 CRC64;
     MSKVDSVLDK YSAKVYKNRK GHMLELEEET QEIAANSRTM PGLINHRGCC YAGCKGVVLG
     PTKDALIITH GPIGCGFYSW GTRRNKAKAE DGGQNYVPYC FSTDLQESDI VFGGEKKLDA
     AIEEAVNIFH PKTIFICATC PVGLIGDDLP AVAKRNSEKY GIDVISFPCE GYKGVSQSAG
     HHIANNIIIR DLIGTVDYKP TKHSVNILGE YNIGGDAWEI KRILTLCGYE VIATFTGDGS
     VDNYRKAHTA DLNVIQCHRS INYIAEMMKI QYGTAWMKGD FIGLDNTIET LREMAKFFDD
     PVLIQQTEKV IADELANISD DMSLYRTKLR GKTAALFVGG SRSHHYQLLL KDFGVKTLLA
     GYEFAHRDDY EGREVIPNIV EDADLKNIEV LNVEKIEDKY KVYKTEEELE ELKKEISELE
     DYKGMERDMD KGSIVVDDLN HYETEEFIKK LKPDMFFSGI KDKFVIQKGG ILSRQLHSYD
     YSGPYAGFKG AVNFGRDVTM GMYTPVWNYT VAPWKKESVL EGKLGGED
//

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