ID W6S4U3_9CLOT Unreviewed; 369 AA.
AC W6S4U3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=3-dehydroquinate synthase {ECO:0000313|EMBL:CDM69362.1};
DE EC=4.2.3.4 {ECO:0000313|EMBL:CDM69362.1};
GN ORFNames=CM240_2219 {ECO:0000313|EMBL:CDM69362.1};
OS Clostridium bornimense.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1216932 {ECO:0000313|EMBL:CDM69362.1, ECO:0000313|Proteomes:UP000019426};
RN [1] {ECO:0000313|EMBL:CDM69362.1, ECO:0000313|Proteomes:UP000019426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M2/40 {ECO:0000313|Proteomes:UP000019426};
RA Wibberg D., Puehler A., Schlueter A.;
RT "Complete genome sequence of Clostridum sp. M2/40.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; HG917868; CDM69362.1; -; Genomic_DNA.
DR AlphaFoldDB; W6S4U3; -.
DR STRING; 1216932.CM240_2219; -.
DR KEGG; clt:CM240_2219; -.
DR PATRIC; fig|1216932.3.peg.2203; -.
DR eggNOG; COG0337; Bacteria.
DR HOGENOM; CLU_001201_0_2_9; -.
DR Proteomes; UP000019426; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR016037; DHQ_synth_AroB.
DR InterPro; IPR030963; DHQ_synth_fam.
DR InterPro; IPR030960; DHQS/DOIS.
DR NCBIfam; TIGR01357; aroB; 1.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF1; 3-DEHYDROQUINATE SYNTHASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR PIRSF; PIRSF001455; DHQ_synth; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CDM69362.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019426};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 72..329
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 369 AA; 41392 MW; D9332B15816F6B31 CRC64;
MNFHVALKKV VDDSYDIEIG YKLEDKLVED IENGLVGEIR NFAIITDSIV EKLYAKNIVS
LLKARNYKCD LFVFEAGEKS KTRKTKEVIE DAMLEKGYRR DCCIIAIGGG VVTDLAGFIA
GTYGRGIPFI NYSTTLLGAA DASVGGKTAV DTELATNLIG LIYQPKKVYI DINTWTTLPR
RQLSSGLCET IKHACIADKE FFKFIEDNIE KIFDFDKAIC THVAESNCRI KYEVVMKDEK
ENNLREILNL GHTVGRAIET VSDYKLLHGE ALSIGIVAEV ILGEKLGYVT LEEKERVINL
LENCGLPIKI PSYINKEELV KKLYTDKKVR NGNIRFVFQK GIGSVMEFEG GKYATVISEE
EIKKVIEVM
//
