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Database: UniProt
Entry: W6THP6_9SPIR
LinkDB: W6THP6_9SPIR
Original site: W6THP6_9SPIR 
ID   W6THP6_9SPIR            Unreviewed;       407 AA.
AC   W6THP6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=BDCR2A_00520 {ECO:0000313|EMBL:ETZ18547.1};
OS   Borrelia duttonii CR2A.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=1432657 {ECO:0000313|EMBL:ETZ18547.1, ECO:0000313|Proteomes:UP000019148};
RN   [1] {ECO:0000313|EMBL:ETZ18547.1, ECO:0000313|Proteomes:UP000019148}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR2A {ECO:0000313|EMBL:ETZ18547.1,
RC   ECO:0000313|Proteomes:UP000019148};
RA   Schwan T.G., Raffel S.J., Porcella S.F.;
RT   "Comparative genomics of relapsing fever spirochetes.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETZ18547.1}.
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DR   EMBL; AZIT01000001; ETZ18547.1; -; Genomic_DNA.
DR   EnsemblBacteria; ETZ18547; ETZ18547; BDCR2A_00520.
DR   PATRIC; fig|1432657.3.peg.514; -.
DR   Proteomes; UP000019148; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.300.180; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019148};
KW   DNA replication {ECO:0000256|RuleBase:RU004227};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019148}.
FT   DOMAIN      174    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   COILED      336    356       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   407 AA;  47604 MW;  AAACD728A723CDBD CRC64;
     MQEGKNIWSL ILAAIRKELS EEEFYIWFEN LYFIDAIGEN IKIATPNSFH KNQVEKRFSK
     RIKEILIEKG HSTINVEFIH SQNELKDHNT ESKDIPLKAI THQQDLQTKN KDIKTHAKNI
     INNTKQYSIK EEIHIKYRNP FLKKKYTFEN FIIGTNNKLA YNASLSIAKN PGKKYNPCLI
     YGGVGLGKTH LLQSIGNKTE ELHKEFKILY VTAENFLNEF VESIKTNETK RFKKKYRHLD
     MLLLDDIHDL QKKEGIQEEL FHTFNALYED NKQMVFTCDR QPSELVNFTD RLKSRFTRGL
     NVDISKPNFE LRVAIIEKKA EEDGIKVPKN ILNLVAKKVT TNIRDLEAAV TKLKAHIDLE
     DIEIDTNIVD KIIKEIIAYE NDNTNTPNKI NIRKYQKSYI KGIKTYK
//
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